Is computer-assisted aminoglycoside dosing managed by a pharmacist a safety tool of pharmacotherapy?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078694" target="_blank" >RIV/00023001:_____/19:00078694 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00112619 RIV/00216208:11160/19:10400789 RIV/00669806:_____/19:10400789 RIV/00209805:_____/19:00078375

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/68/68_S87.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/68/68_S87.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.934329" target="_blank" >10.33549/physiolres.934329</a>

Result language

angličtina

Original language name

Is computer-assisted aminoglycoside dosing managed by a pharmacist a safety tool of pharmacotherapy?

Original language description

This pilot prospective study verified the hypothesis that use of computer-assisted therapeutic drug monitoring of aminoglycosides by pharmacists leads to better safety therapeutic outcomes and cost avoidance than only concentration measurement and dose adjustments based on a physician&apos;s experience. Two groups of patients were enrolled according to the technique of monitoring. Patients (Group 1, n=52) underwent monitoring by a pharmacist using pharmacokinetic software. In a control group (Group 2, n=11), plasma levels were measured but not interpreted by the pharmacist, only by physicians. No statistically significant differences were found between the groups in factors influenced by therapy. However, the results are not statistically significant but a comparison of the groups showed a clear trend towards safety and cost avoidance, thus supporting therapeutic drug monitoring. Safety limits were achieved in 76 % and 63 % of cases in Groups 1 and 2, respectively. More patients achieved both concentrations (peak and trough) with falling eGFR in Group 1. In present pilot study, the pharmacist improved the care of patients on aminoglycoside therapy. A larger study is needed to demonstrate statistically significantly improved safety and cost avoidance of aminoglycoside therapy monitoring by the pharmacist using pharmacokinetic software.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

—

Volume of the periodical

68

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

"S87"-"S96"

UT code for WoS article

000499085100010

EID of the result in the Scopus database

2-s2.0-85075326818