Non-traditional administration of remifentanil in an experimental setting

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078695" target="_blank" >RIV/00023001:_____/19:00078695 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/19:43919124 RIV/00064173:_____/19:N0000142
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/68/68_S97.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/68/68_S97.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934330" target="_blank" >10.33549/physiolres.934330</a>

Result language
angličtina
Original language name
Non-traditional administration of remifentanil in an experimental setting
Original language description
Remifentanil is ultrashort-acting opioid with a unique pharmacokinetic profile. It is used exclusively intravenously. While considering its rapid onset of action and other pharmacokinetic properties, we decided to assess its effects following administration via non-traditional routes. Rabbits (n=10 per each group) were randomized into six groups: remifentanil 1 mu g/kg and 3 mu g/kg IM, 5.0 and 10.0 mu g/kg conjunctivally, and 10 mu g/kg and 25.0 mu g/kg intranasally. Sedating effects were assessed via a loss of the righting reflex. Secondary, mean arterial blood pressure, arterial oxygen saturation of hemoglobin, and pulse rate was monitored in all rabbits. Non-traditional routes of administration were shown to provide a rapid onset of action as well as fast recovery. Importantly, the administration of remifentanil did not result in any deterioration of cardiovascular functions.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30223 - Anaesthesiology

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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