Dialysis therapy is associated with peripheral marginal zone B-cell augmentation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00079644" target="_blank" >RIV/00023001:_____/20:00079644 - isvavai.cz</a>
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0966327420300356?token=7452FC205B09E41AD1AE98D0045F1CF941F014570C93838722A396F0A92F42D537D636E4A82FF047F4B7455CCBC730AE" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0966327420300356?token=7452FC205B09E41AD1AE98D0045F1CF941F014570C93838722A396F0A92F42D537D636E4A82FF047F4B7455CCBC730AE</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.trim.2020.101289" target="_blank" >10.1016/j.trim.2020.101289</a>

Result language
angličtina
Original language name
Dialysis therapy is associated with peripheral marginal zone B-cell augmentation
Original language description
Chronic kidney disease stage 5 (CKD5) dialysis patients who stay long term in uremic environment often exhibit several, poorly defined, immune impairments. In this study, we assessed peripheral virus-specific effector/memory cells and subpopulations of T, B and DC cells using ELISPOT and FACS methods in 74 low-risk kidney transplant candidates without anti-HLA antibodies, prior to transplantation in pre-emptive (never experienced dialysis) and dialysis cohorts. There was difference in circulating marginal zone B cells (MZB) (IgD(high)CD27(high)) between dialysis patients and those receiving kidney grafts pre-emptively (P = .002). Patients treated on dialysis > 12 months had also 4.2-fold greater risk of increased absolute numbers of MZB (95%CI:1.6-11.2; P = .004). There were no other differences in B-, T- and DC-cell subsets. Numbers of effector/memory T cells reactive to major opportunistic virus-specific antigens (CMV, BKV and EBV) were not affected by dialysis. Nonsensitised dialysis-treated patients displayed significantly more circulating MZB compared to those CKD5 patients that had never undergone dialysis therapy.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation

Project
<a href="/en/project/7E13020" target="_blank" >7E13020: Personalized minimization of immunosuppression after solid organ transplantation by biomarker-driven stratification of patients to improve long-term outcome and health-economic data of transplantation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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