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Complete recovery of fulminant cytotoxic CD8 T-cell-mediated myocarditis after ECMELLA unloading and immunosuppression

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00079707" target="_blank" >RIV/00023001:_____/20:00079707 - isvavai.cz</a>

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ehf2.12697" target="_blank" >https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ehf2.12697</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/ehf2.12697" target="_blank" >10.1002/ehf2.12697</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Complete recovery of fulminant cytotoxic CD8 T-cell-mediated myocarditis after ECMELLA unloading and immunosuppression

  • Original language description

    A 19-year-old woman with no previous cardiac history was admitted to the hospital with third-degree atrioventricular block and left ventricular dysfunction. Her condition quickly deteriorated to severe biventricular failure and cardiogenic shock requiring mechanical circulatory support. An endomyocardial biopsy revealed lymphocytic myocarditis with no PCR-detectable viral genomes, with CD8 T-cell predominance and pro-inflammatory macrophage expansion shown by myocardial flow cytometry. The therapy consisted of immunosuppression (high-dose methylprednisolone) and temporary mechanical circulatory support with enhanced ability to achieve left ventricular unloading by combination of extracorporeal membrane oxygenation with Impella (ECMELLA). After 2 weeks of support, complete and sustained recovery from myocarditis was observed.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

    <a href="/en/project/NV17-28784A" target="_blank" >NV17-28784A: Mechanisms of right ventricular dysfunction in chronic heart failure</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    ESC heart failure [online]

  • ISSN

    2055-5822

  • e-ISSN

  • Volume of the periodical

    2020

  • Issue of the periodical within the volume

    June

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    1976-1981

  • UT code for WoS article

    000536989700001

  • EID of the result in the Scopus database

    2-s2.0-85085688731