Complete recovery of fulminant cytotoxic CD8 T-cell-mediated myocarditis after ECMELLA unloading and immunosuppression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00079707" target="_blank" >RIV/00023001:_____/20:00079707 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ehf2.12697" target="_blank" >https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ehf2.12697</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ehf2.12697" target="_blank" >10.1002/ehf2.12697</a>
Alternative languages
Result language
angličtina
Original language name
Complete recovery of fulminant cytotoxic CD8 T-cell-mediated myocarditis after ECMELLA unloading and immunosuppression
Original language description
A 19-year-old woman with no previous cardiac history was admitted to the hospital with third-degree atrioventricular block and left ventricular dysfunction. Her condition quickly deteriorated to severe biventricular failure and cardiogenic shock requiring mechanical circulatory support. An endomyocardial biopsy revealed lymphocytic myocarditis with no PCR-detectable viral genomes, with CD8 T-cell predominance and pro-inflammatory macrophage expansion shown by myocardial flow cytometry. The therapy consisted of immunosuppression (high-dose methylprednisolone) and temporary mechanical circulatory support with enhanced ability to achieve left ventricular unloading by combination of extracorporeal membrane oxygenation with Impella (ECMELLA). After 2 weeks of support, complete and sustained recovery from myocarditis was observed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV17-28784A" target="_blank" >NV17-28784A: Mechanisms of right ventricular dysfunction in chronic heart failure</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ESC heart failure [online]
ISSN
2055-5822
e-ISSN
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Volume of the periodical
2020
Issue of the periodical within the volume
June
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
1976-1981
UT code for WoS article
000536989700001
EID of the result in the Scopus database
2-s2.0-85085688731