Longterm survival after liver transplantation for autoimmune hepatitis: results from the European liver transplant registry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00079780" target="_blank" >RIV/00023001:_____/20:00079780 - isvavai.cz</a>

Result on the web

<a href="https://aasldpubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/lt.25739" target="_blank" >https://aasldpubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/lt.25739</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/lt.25739" target="_blank" >10.1002/lt.25739</a>

Result language

angličtina

Original language name

Longterm survival after liver transplantation for autoimmune hepatitis: results from the European liver transplant registry

Original language description

The aim of this study was to analyze longterm patient and graft survival after liver transplantation for autoimmune hepatitis (AIH-LT) from the prospective multicenter European Liver Transplant Registry. Patient and liver graft survival between 1998 and 2017 were analyzed. Patients after AIH-LT (n = 2515) were compared with patients receiving LT for primary biliary cholangitis (PBC-LT; n = 3733), primary sclerosing cholangitis (PSC-LT; n = 5155), and alcohol-related cirrhosis (AC-LT; n = 19,567). After AIH-LT, patient survival was 79.4%, 70.8%, and 60.3% and graft survival was 73.2%, 63.4%, and 50.9% after 5, 10, and 15 years of follow-up. Overall patient survival was similar to patients after AC-LT (P = 0.44), but worse than after PBC-LT (hazard ratio [HR], 1.48; P &lt; 0.001) and PSC-LT (HR, 1.19; P = 0.002). AIH-LT patients were at increased risk for death (HR, 1.37-1.84; P &lt; 0.001) and graft loss (HR, 1.35-1.80; P &lt; 0.001) from infections compared with all other groups and had a particularly increased risk for lethal fungal infections (HR, 3.38-4.20; P &lt;= 0.004). Excluding patients who died within 90 days after LT, risk of death after AIH-LT was superior compared with AC-LT (HR, 0.84; P = 0.004), worse compared with PBC-LT (HR, 1.38; P &lt; 0.001) and similar compared with PSC-LT (P = 0.93). Autoimmune hepatitis (AIH) patients with living donor liver transplantation (LDLT) showed reduced survival compared with patients receiving donation after brain death (HR, 1.96; P &lt; 0.001). In AIH-LT patients, overall survival is inferior to PBC-LT and PSC-LT. The high risk of death after AIH-LT is caused mainly by early fatal infections, including fungal infections. Patients with LDLT for AIH show reduced survival.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30213 - Transplantation

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Liver transplantation

ISSN

1527-6465

e-ISSN

—

Volume of the periodical

26

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

866-877

UT code for WoS article

000529682400001

EID of the result in the Scopus database

2-s2.0-85084228840