Fluorinated water-soluble poly(2-oxazoline)s as highly sensitive F-19 MRI contrast agents

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00080033" target="_blank" >RIV/00023001:_____/20:00080033 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.macromol.0c01228" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.macromol.0c01228</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.macromol.0c01228" target="_blank" >10.1021/acs.macromol.0c01228</a>

Result language
angličtina
Original language name
Fluorinated water-soluble poly(2-oxazoline)s as highly sensitive F-19 MRI contrast agents
Original language description
Recently, F-19 magnetic resonance imaging (MRI) emerged as a powerful noninvasive diagnostic tool in modern medicine. Fluorinated polymer materials represent an attractive class of MRI contrast agents (CAs) due to their structural variability and tunable properties. Herein, we describe for the first time the F-19 MRI of CAs based on fluorinated water-soluble poly(2-oxazoline)s (PAOx), a polymer class with increasing popularity in biomedical sciences. A series of fluorinated PAOx with increasing fluorine content were synthesized by controlled side-chain hydrolysis of poly(2- methyl-2-oxazoline) followed by reacylation of its ethylenimine units by difluoroacetic anhydride. As the increasing fluorine content leads to the copolymer hydrophobization, their composition was optimized for maximal F-19 MRI performance while retaining good solubility in water. The magnetic properties of the water-soluble polymers were studied in vitro by F-19 NMR and MRI, revealing their outstanding relaxation properties and imaging sensitivity. All CAs were found to be noncytotoxic for HeLa cells in vitro. Finally, the diagnostic potential of the new CAs was demonstrated by a successful in vivo F-19 MRI visualization of the selected fluorinated polymer in rats.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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