Interleukin-1 Blockade in Polygenic Autoinflammatory Disorders: Where Are We now?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080785" target="_blank" >RIV/00023001:_____/21:00080785 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/21:10424710 RIV/00216208:11130/21:10424710
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fphar.2020.619273/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fphar.2020.619273/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fphar.2020.619273" target="_blank" >10.3389/fphar.2020.619273</a>
Alternative languages
Result language
angličtina
Original language name
Interleukin-1 Blockade in Polygenic Autoinflammatory Disorders: Where Are We now?
Original language description
Polygenic autoinflammatory diseases (AIDs), such as systemic juvenile idiopathic arthritis (sJIA), adult-onset Still's disease, Kawasaki disease, idiopathic recurrent pericarditis (IRP), Behcet's Syndrome, Crystal-induced arthropatihes such as gout or Calcium pyrophosphate deposition disease are characterized by the overexpression of inflammasome-associated genes, leading to a dysregulation of the innate immune response. The IL-1 cytokine family (IL-1 alpha, IL-1 beta, IL-1Ra, IL-18, IL-36Ra, IL-36 alpha, IL-37, IL-36 beta, IL-36g, IL-38, IL-33) was defined to be principally responsible for the inflammatory nature of polygenic AIDs. Several clinical trials were initiated, and IL-1 blockade has been proven to cause a rapid reduction of clinical symptoms and normalization of laboratory parameters in the majority of cases. Randomized, placebo-controlled, clinical trials, together with registry-based clinical trials and open-label, retrospective and prospective observational studies, supported the efficacy and safety of IL-1 inhibitors in the treatment of polygenic AIDs. Most of the current data are focused on the therapeutic use of anakinra, an IL-1 receptor antagonist, canakinumab, an anti-IL-1 beta monoclonal antibody, and rilonacept, a soluble decoy receptor. However, other promising agents, such as gevokizumab, IL-1 beta blocking monoclonal antibody, tadekinig alfa, a human recombinant IL-18-binding protein, and tranilast, an analog of a tryptophan metabolite, are currently being tested. Anakinra, canakinumab and rilonacept caused impressive improvements in both systemic and musculoskeletal symptoms. Furthermore, the anti-IL-1 therapy allowed corticosteroid tapering and, in some cases, even withdrawal. This article reviews the current IL-1 inhibitors and the results of all clinical trials in which they have been tested for the management of broad spectrum of polygenic AIDs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/NU20-05-00320" target="_blank" >NU20-05-00320: Neutrophils in juvenile idiopathic arthritis: biomarkers with potential to improve clinical treatment decisions and patient care</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in pharmacology [online]
ISSN
1663-9812
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
January 26
Country of publishing house
CH - SWITZERLAND
Number of pages
21
Pages from-to
"art. no. 619273"
UT code for WoS article
000616159800001
EID of the result in the Scopus database
2-s2.0-85100813252