Serum S100 Protein Is a Reliable Predictor of Brain Injury After Out-of-Hospital Cardiac Arrest: A Cohort Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080793" target="_blank" >RIV/00023001:_____/21:00080793 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43921197 RIV/00216208:11110/21:10425182
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fcvm.2021.624825/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcvm.2021.624825/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcvm.2021.624825" target="_blank" >10.3389/fcvm.2021.624825</a>
Alternative languages
Result language
angličtina
Original language name
Serum S100 Protein Is a Reliable Predictor of Brain Injury After Out-of-Hospital Cardiac Arrest: A Cohort Study
Original language description
Purpose: To evaluate serum S100 protein at hospital admission and after 48 h in early neuroprognostication of comatose survivors of out-of-hospital cardiac arrest (OHCA). Methods: The study included 48 consecutive patients after OHCA, who survived for at least 72 h after the event. The patients were divided based on their best cerebral performance category (CPC) achieved over a 30 day follow-up period: favorable neurological outcome (CPC 1-2) vs. unfavorable neurological outcome (CPC 3-4). Predictors of an unfavorable neurological outcome were identified by multivariable regression analysis. Analysis of the receiver operating characteristic curve (ROC) was used to determine the cut-off value for S100, having a 0% false-positive prediction rate. Results: Of the 48 patients, 30 (63%) had a favorable and 18 (38%) had an unfavorable neurological outcome. Eleven patients (23%) died over the 30 day follow-up. Increased S100 levels at 48 h after OHCA, but not the baseline S100 levels, were independently associated with unfavorable neurological outcome, with an area under the ROC curve of 0.85 (confidence interval 0.74-0.96). A 48 h S100 value >= 0.37 mu g/L had a specificity of 100% and sensitivity of 39% in predicting an unfavorable 30 day neurological outcome. Conclusion: This study showed that S100 values assessed 48 h after an OHCA could independently predict an unfavorable neurological outcome at 30 days.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in cardiovascular medicine
ISSN
2297-055X
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
February 9
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
"art. no. 624825"
UT code for WoS article
000620585700001
EID of the result in the Scopus database
2-s2.0-85126871799