Ellagic acid affects metabolic and transcriptomic profiles and attenuates features of metabolic syndrome in adult male rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080797" target="_blank" >RIV/00023001:_____/21:00080797 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10427990 RIV/00064165:_____/21:10427990
Result on the web
<a href="https://www.mdpi.com/2072-6643/13/3/804/htm" target="_blank" >https://www.mdpi.com/2072-6643/13/3/804/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/nu13030804" target="_blank" >10.3390/nu13030804</a>
Alternative languages
Result language
angličtina
Original language name
Ellagic acid affects metabolic and transcriptomic profiles and attenuates features of metabolic syndrome in adult male rats
Original language description
Ellagic acid, a natural substance found in various fruits and nuts, was previously shown to exhibit beneficial effects towards metabolic syndrome. In this study, using a genetic rat model of metabolic syndrome, we aimed to further specify metabolic and transcriptomic responses to ellagic acid treatment. Adult male rats of the SHR-Zbtb16Lx/k.o. strain were fed a high-fat diet accompanied by daily intragastric gavage of ellagic acid (50 mg/kg body weight; high-fat diet–ellagic acid (HFD-EA) rats) or vehicle only (high-fat diet–control (HFD-CTL) rats). Morphometric and metabolic parameters, along with transcriptomic profile of liver and brown and epididymal adipose tissues, were assessed. HFD-EA rats showed higher relative weight of brown adipose tissue (BAT) and decreased weight of epididymal adipose tissue, although no change in total body weight was observed. Glucose area under the curve, serum insulin, and cholesterol levels, as well as the level of oxidative stress, were significantly lower in HFD-EA rats. The most differentially expressed tran-scripts reflecting the shift induced by ellagic acid were detected in BAT, showing downregulation of BAT activation markers Dio2 and Nr4a1 and upregulation of insulin-sensitizing gene Pla2g2a. Ellagic acid may provide a useful nutritional supplement to ameliorate features of metabolic syn-drome, possibly by suppressing oxidative stress and its effects on brown adipose tissue. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nutrients
ISSN
2072-6643
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
3
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
"art. no. 804"
UT code for WoS article
000633978300001
EID of the result in the Scopus database
2-s2.0-85101710712