Different expression of mitochondrial and endoplasmic reticulum stress genes in epicardial adipose tissue depends on coronary atherosclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080977" target="_blank" >RIV/00023001:_____/21:00080977 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/1422-0067/22/9/4538" target="_blank" >https://www.mdpi.com/1422-0067/22/9/4538</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms22094538" target="_blank" >10.3390/ijms22094538</a>

Result language

angličtina

Original language name

Different expression of mitochondrial and endoplasmic reticulum stress genes in epicardial adipose tissue depends on coronary atherosclerosis

Original language description

The aim of our study was to analyze mitochondrial and endoplasmic reticulum (ER) gene expression profiles in subcutaneous (SAT) and epicardial (EAT) adipose tissue, skeletal muscle, and myocardium in patients with and without CAD undergoing elective cardiac surgery. Thirty-eight patients, 27 with (CAD group) and 11 without CAD (noCAD group), undergoing coronary artery bypass grafting and/or valvular surgery were included in the study. EAT, SAT, intercostal skeletal muscle, and right atrium tissue and blood samples were collected at the start and end of surgery; mRNA expression of selected mitochondrial and ER stress genes was assessed using qRT-PCR. The presence of CAD was associated with decreased mRNA expression of most of the investigated mitochondrial respiratory chain genes in EAT, while no such changes were seen in SAT or other tissues. In contrast, the expression of ER stress genes did not differ between the CAD and noCAD groups in almost any tissue. Cardiac surgery further augmented mitochondrial dysfunction in EAT. In our study, CAD was associated with decreased expression of mitochondrial, but not endoplasmic reticulum stress genes in EAT. These changes may contribute to the acceleration of coronary atherosclerosis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV19-02-00118" target="_blank" >NV19-02-00118: The role of epicardial fat, subclinical inflammation and novel lipid signalling molecules in the onset and development of heart failure</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of molecular sciences

ISSN

1661-6596

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

"art. no. 4538"

UT code for WoS article

000650414500001

EID of the result in the Scopus database

2-s2.0-85104585671