Therapy of chronic hepatitis C in people who inject drugs: focus on adherence
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081175" target="_blank" >RIV/00023001:_____/21:00081175 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10429512 RIV/00064165:_____/21:10429512
Result on the web
<a href="https://harmreductionjournal.biomedcentral.com/track/pdf/10.1186/s12954-021-00519-y.pdf" target="_blank" >https://harmreductionjournal.biomedcentral.com/track/pdf/10.1186/s12954-021-00519-y.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12954-021-00519-y" target="_blank" >10.1186/s12954-021-00519-y</a>
Alternative languages
Result language
angličtina
Original language name
Therapy of chronic hepatitis C in people who inject drugs: focus on adherence
Original language description
BackgroundIntravenous drug use (IVDU) represents the major factor of HCV transmission, but the treatment uptake among people who inject drugs (PWID) remains low owing to a false presumption of low efficacy. The aim of our study was to assess treatment efficacy in PWID and factors determining adherence to therapy.MethodsA total of 278 consecutive patients starting DAA (direct-acting antivirals) therapy were included, divided into two groups: individuals with a history of IVDU, PWID group (N=101) and the control group (N=177) without a history of IVDU.ResultsSustained virological response 12 weeks after the end of therapy (SVR12) was achieved by 99/101 (98%) and 172/177 (98%) patients in the PWID and control group, respectively; in PWID group, two patients were lost to follow-up, and in the control group, four patients relapsed and one was lost to follow-up. PWID patients postponed appointments significantly more often, 29 (28.7%) in PWID versus 7 (4%) in the control group, p=0.001. Thirteen of 101 (12.9%) and six of 177 (3.4%) patients in the PWID and in the control group, respectively, missed at least one visit (p<0.01). However, postponing visits led to a lack of medication in only one PWID. In the PWID group, older age (p<0.05; OR 1.07, 95% CI 1.00-1.20) and stable housing (p<0.01; OR 9.70, 95% CI 2.10-56.20) were factors positively contributing to adherence. Contrarily, a stable job was a factor negatively influencing adherence (p<0.05; OR 0.24, 95% CI 0.06-0.81). In the control group, none of the analyzed social and demographic factors had an impact on adherence to therapy.ConclusionsIn PWID, treatment efficacy was excellent and was comparable with SVR of the control group. Stable housing and older age contributed to a better adherence to therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30312 - Substance abuse
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Harm reduction journal
ISSN
1477-7517
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
"art. no. 69"
UT code for WoS article
000671233500002
EID of the result in the Scopus database
2-s2.0-85109021094