Giant cell myocarditis in young woman diagnosed at the autopsy: a case report

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081533" target="_blank" >RIV/00023001:_____/21:00081533 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43922037 RIV/00064173:_____/21:N0000095
Result on the web
<a href="https://www.prolekare.cz/casopisy/cesko-slovenska-patologie/2021-3-14/obrovskobunecna-myokarditida-u-mlade-zeny-odhalena-pri-pitve-kazuistika-128091/download?hl=cs" target="_blank" >https://www.prolekare.cz/casopisy/cesko-slovenska-patologie/2021-3-14/obrovskobunecna-myokarditida-u-mlade-zeny-odhalena-pri-pitve-kazuistika-128091/download?hl=cs</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Giant cell myocarditis in young woman diagnosed at the autopsy: a case report
Original language description
Giant cell myocarditis (GCM) is a rare inflammatory disease of the heart that often affects younger patients. The clinical course is typically rapid with fulminant congestive heart failure. Prognosis is poor; the proper diagnosis is often rendered at the autopsy.Herein, we present a prototypical case of this rare type of myocarditis, affecting a 44-year-old previously healthy woman who was referred to the intensive care department due to an acute onset cardiac arrest followed by resuscitation. The heart ultrasound and imaging examinations revealed a severe dysfunction and dilatation of both ventricles, without any significant finding in the coronary arteries. Twelve days after the initial presentation, the patient died due to congestive heart failure refractory to intensive therapy. The post-mortem histology of the heart revealed multiple small necrotic foci in the myocardium in both ventricles, with dense inflammatory infiltration with abundant multinucleated giant histiocytes, in line with a diagnosis of GCM.The natural history, pathophysiology, and histological differential diagnosis is discussed, together with review of the relevant literature including uncommon and emerging units.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30109 - Pathology

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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