Very low lipoprotein(a) and increased mortality risk after myocardial infarction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081536" target="_blank" >RIV/00023001:_____/21:00081536 - isvavai.cz</a>
Alternative codes found
RIV/00064190:_____/21:N0000038 RIV/00216208:11120/21:43922056 RIV/00216208:11110/21:10431419
Result on the web
<a href="https://www.ejinme.com/article/S0953-6205(21)00135-7/pdf" target="_blank" >https://www.ejinme.com/article/S0953-6205(21)00135-7/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejim.2021.04.012" target="_blank" >10.1016/j.ejim.2021.04.012</a>
Alternative languages
Result language
angličtina
Original language name
Very low lipoprotein(a) and increased mortality risk after myocardial infarction
Original language description
Background: Inconclusive data exist on risk associated with Lp(a) in patients after myocardial infarction (MI). Aims of the present study were to evaluate the association of Lp(a) level with total mortality and recurrent cardiovascular events. Design and methods: Single center prospective registry of consecutive patients hospitalized for acute myocardial infarction between June 2017 and June 2020 at a large tertiary cardiac center with available blood samples drawn <24h of admission. Results: Data from 851 consecutive patients hospitalized for MI were evaluated. During the median follow-up of 19 months (interquartile range 10-27), 58 (6.8%) patients died. Nonlinear modelling revealed a U-shaped as-sociation between Lp(a) and total mortality risk. Compared to patients with Lp(a) ranging between 10-30 nmol/L and after multivariate adjustment, total mortality risk was increased both in patients with Lp(a) 7 nmol/L (hazard ratio (HR) 4.08, 95% confidence interval (CI) 1.72-9.68) and Lp(a) 125 nmol/L (HR 2.92, 95% CI 1.16-7.37), respectively. Similarly, the risk of combined endpoint of acute coronary syndrome recurrence or cardiovascular mortality was increased both in patients with low (sub-HR 2.60, 95% CI 1.33-5.08) and high (sub-HR 2.10, 95% CI 1.00-4.39) Lp(a). Adjustment for heart failure signs at the time of hospitalization weakened the association with total mortality and recurrent cardiovascular events. Conclusions: In the present analysis, both high and low concentrations of Lp(a) were associated with an increased risk of total mortality and recurrent cardiovascular events after MI. The excess of mortality associated with Lp(a) was partially attributable to more prevalent heart failure.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV19-09-00125" target="_blank" >NV19-09-00125: Novel tools to improve cardiovascular prevention after myocardial infarction</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European journal of internal medicine
ISSN
0953-6205
e-ISSN
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Volume of the periodical
91
Issue of the periodical within the volume
September 2021
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
33-39
UT code for WoS article
000690383400007
EID of the result in the Scopus database
2-s2.0-85105484387