Increased pulsatility index is associated with adverse outcomes in left ventricular assist device recipients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081716" target="_blank" >RIV/00023001:_____/21:00081716 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43921832 RIV/00216208:11110/21:10429896 RIV/00216208:11130/21:10429896
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ehf2.13537" target="_blank" >https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ehf2.13537</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ehf2.13537" target="_blank" >10.1002/ehf2.13537</a>
Alternative languages
Result language
angličtina
Original language name
Increased pulsatility index is associated with adverse outcomes in left ventricular assist device recipients
Original language description
Aims Recipients of left ventricular assist devices (LVAD) are exposed to increased risk of adverse clinical events. One of the potential contributing factors is non-pulsatile flow generated by LVAD. We evaluated the association of flow patterns in carotid arteries and of increased arterial stiffness with death and cerebrovascular events in LVAD recipients. Methods and results We analysed data from 83 patients [mean age 54 +/- 15 years; 12 women; HeartMate II (HMII), n = 34; HeartMate 3 (HM3), n = 49]. Pulsatile and resistive indexes, atherosclerotic changes in carotid arteries (measured by duplex ultrasound), and arterial stiffness [measured by Endo-PAT 2000 as the augmentation index standardized for heart rate (AI@75)] were evaluated 3 and 6 months after LVAD implantation. Sixteen patients died during follow-up (27.3 months; interquartile range 15.7-44.3). After adjusting for the main variables examined, the pulsatility index measured at 3 months was positively associated with increased hazard ratios (HR) for death and cerebrovascular events [HR 9.8, 95% confidence interval (CI) 1.62-59.42], with HR increasing after adding AI@75 to the model (HR 18.8, 95% CI 2.44-145.50). In HM3 recipients, HR was significantly lower than in HMII recipients (HR 0.31, 95% CI 0.11-0.91), but the significance disappeared after adding AI@75 to the model (HR 0.33, 95% CI 0.09-1.18). Conclusions The risk of death and cerebrovascular events in LVAD recipients is associated with increased pulsatility index in carotid arteries and potentiated by increased arterial stiffness. The same risk is attenuated by HM3 LVAD implantation, but this effect is weakened by increased arterial stiffness.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV16-27630A" target="_blank" >NV16-27630A: Markers of vascular health in patients with implanted mechanical circulatory support</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ESC heart failure [online]
ISSN
2055-5822
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
4288-4295
UT code for WoS article
000680928900001
EID of the result in the Scopus database
2-s2.0-85111726904