First Clinical Experience With the Pressure Sensor-Based Autoregulation of Blood Flow in an Artificial Heart
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081748" target="_blank" >RIV/00023001:_____/21:00081748 - isvavai.cz</a>
Result on the web
<a href="https://journals.lww.com/asaiojournal/Fulltext/2021/10000/First_Clinical_Experience_With_the_Pressure.4.aspx" target="_blank" >https://journals.lww.com/asaiojournal/Fulltext/2021/10000/First_Clinical_Experience_With_the_Pressure.4.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MAT.0000000000001485" target="_blank" >10.1097/MAT.0000000000001485</a>
Alternative languages
Result language
angličtina
Original language name
First Clinical Experience With the Pressure Sensor-Based Autoregulation of Blood Flow in an Artificial Heart
Original language description
The CARMAT-Total Artificial Heart (C-TAH) is designed to provide heart replacement therapy for patients with end-stage biventricular failure. This report details the reliability and efficacy of the autoregulation device control mechanism (auto-mode), designed to mimic normal physiologic responses to changing patient needs. Hemodynamic data from a continuous cohort of 10 patients implanted with the device, recorded over 1,842 support days in auto-mode, were analyzed with respect to daily changing physiologic needs. The C-TAH uses embedded pressure sensors to regulate the pump output. Right and left ventricular outputs are automatically balanced. The operator sets target values and the inbuilt algorithm adjusts the stroke volume and beat rate, and hence cardiac output, automatically. Auto-mode is set perioperatively after initial postcardiopulmonary bypass hemodynamic stabilization. All patients showed a range of average inflow pressures of between 5 and 20 mm Hg during their daily activities, resulting in cardiac output responses of between 4.3 and 7.3 L/min. Operator adjustments were cumulatively only required on 20 occasions. This report demonstrates that the C-TAH auto-mode effectively produces appropriate physiologic responses reflective of changing patients' daily needs and represents one of the unique characteristics of this device in providing almost physiologic heart replacement therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ASAIO journal
ISSN
1058-2916
e-ISSN
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Volume of the periodical
67
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1100-1108
UT code for WoS article
000756955200008
EID of the result in the Scopus database
2-s2.0-85117740066