Longitudinal trajectories of blood lipid levels in an ageing population sample of Russian Western-Siberian urban population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081914" target="_blank" >RIV/00023001:_____/21:00081914 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10436174
Result on the web
<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260229#sec013" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260229#sec013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0260229" target="_blank" >10.1371/journal.pone.0260229</a>
Alternative languages
Result language
angličtina
Original language name
Longitudinal trajectories of blood lipid levels in an ageing population sample of Russian Western-Siberian urban population
Original language description
This study investigated 12-year blood lipid trajectories and whether these trajectories are modified by smoking and lipid lowering treatment in older Russians. To do so, we analysed data on 9,218 Russian West-Siberian Caucasians aged 45–69 years at baseline participating in the international HAPIEE cohort study. Mixed-effect multilevel models were used to estimate individual level lipid trajectories across the baseline and two follow-up examinations (16,445 separate measurements over 12 years). In all age groups, we observed a reduction in serum total cholesterol (TC), LDL-C and non-HDL-C over time even after adjusting for sex, statin treatment, hypertension, diabetes, social factors and mortality (P<0.01). In contrast, serum triglyceride (TG) values increased over time in younger age groups, reached a plateau and decreased in older age groups (> 60 years at baseline). In smokers, TC, LDL-C, non-HDL-C and TG decreased less markedly than in non-smokers, while HDL-C decreased more rapidly while the LDL-C/HDL-C ratio increased. In subjects treated with lipid-lowering drugs, TC, LDL-C and non-HDL-C decreased more markedly and HDL-C less markedly than in untreated subjects while TG and LDL-C/HDL-C remained stable or increased in treatment naïve subjects. We conclude, that in this ageing population we observed marked changes in blood lipids over a 12 year follow up, with decreasing trajectories of TC, LDL-C and non-HDL-C and mixed trajectories of TG. The findings suggest that monitoring of age-related trajectories in blood lipids may improve prediction of CVD risk beyond single measurements. Copyright: © 2021 Hubacek et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE [online]
ISSN
1932-6203
e-ISSN
—
Volume of the periodical
16
Issue of the periodical within the volume
12 December
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
"art. no. e0260229"
UT code for WoS article
000735299000039
EID of the result in the Scopus database
2-s2.0-85120711447