Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081927" target="_blank" >RIV/00023001:_____/21:00081927 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10436670
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2021/70_S125.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2021/70_S125.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934730" target="_blank" >10.33549/physiolres.934730</a>
Alternative languages
Result language
angličtina
Original language name
Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression
Original language description
Genetic predispositions may influence geographical and interethnic differences in COVID-19 prevalence and mortality in affected populations. Of the many genes implicated in COVID-19 progression, a substantial number have no direct functional link on virus transfer/viability or on the host immune system. To address this knowledge deficit, a large number of in silico studies have recently been published. However, the results of these studies often contradict the findings of studies involving real patients. For example, the ACE2 has been shown to play an important role in regulating coronavirus entry into cells, but none of its variations have been directly associated with COVID-19 susceptibility or severity. Consistently was reported that increased risk of COVID-19 is associated with blood group A and with the APOE4 allele. Among other genes with potential impacts are the genes for CCR5, IL-10, CD14, TMPRSS2 and angiotensin-converting enzyme. Variants within the protein-coding genes OAS1 and LZTFL1 (transferred to the human genome from Neanderthals) are understood to be among the strongest predictors of disease severity. The intensive research efforts have helped to identify the genes and polymorphisms that contribute to SARS-CoV-2 infection and COVID-19 severity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
70
Issue of the periodical within the volume
Supplement 2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
10
Pages from-to
"S125"-"S134"
UT code for WoS article
000740730700003
EID of the result in the Scopus database
2-s2.0-85122773498