SARS-CoV-2 viral load assessment in lung transplantation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081940" target="_blank" >RIV/00023001:_____/21:00081940 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10435314 RIV/00064203:_____/21:10435314 RIV/00216208:11130/21:10435314

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/70/70_S253.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/70/70_S253.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.934760" target="_blank" >10.33549/physiolres.934760</a>

Result language

angličtina

Original language name

SARS-CoV-2 viral load assessment in lung transplantation

Original language description

In the era of COVID-19 pandemic, organ transplantation programs were facing serious challenges. The lung transplantation donor pool was extremely limited and SARS-CoV-2 viral load assessment has become a crucial part of selecting an optimal organ donor. Since COVID-19 is a respiratory disease, the viral load is thought to be more important in lung transplantations as compared to other solid organ transplantations. We present two challenging cases of potential lung donors with a questionable COVID-19 status. Based on these cases, we suggest that the cycle threshold (Ct) value should always be requested from the laboratory and the decision whether to proceed with transplantation should be made upon complex evaluation of diverse criteria, including the nasopharyngeal swab and bronchoalveolar lavage PCR results, the Ct value, imaging findings and the medical history. However, as the presence of viral RNA does not ensure infectivity, it is still to be clarified which Ct values are associated with the viral viability. Anti-SARS-CoV-2 IgA antibodies may support the diagnosis and moreover, novel methods, such as quantifying SARS-CoV-2 nucleocapsid antigen in serum may provide important answers in organ transplantations and donor selections.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30213 - Transplantation

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

—

Volume of the periodical

70

Issue of the periodical within the volume

S2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

"S253"-"S258"

UT code for WoS article

000740730700013

EID of the result in the Scopus database

2-s2.0-85122773266