Chronic venous disease and diabetic microangiopathy: pathophysiology and commonalities

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081949" target="_blank" >RIV/00023001:_____/21:00081949 - isvavai.cz</a>

Result on the web

<a href="https://www.minervamedica.it/en/getfreepdf/NEtEdS9vc3dFRjVKZExEWjNGc0ZTdkJyMlZLQlJCMlBsYlpwaEVwdU1KZTE4WkgveFVrOWE3OElvcUd2WjVxRQ%253D%253D/R34Y2021N06A0457.pdf" target="_blank" >https://www.minervamedica.it/en/getfreepdf/NEtEdS9vc3dFRjVKZExEWjNGc0ZTdkJyMlZLQlJCMlBsYlpwaEVwdU1KZTE4WkgveFVrOWE3OElvcUd2WjVxRQ%253D%253D/R34Y2021N06A0457.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23736/S0392-9590.21.04664-2" target="_blank" >10.23736/S0392-9590.21.04664-2</a>

Result language

angličtina

Original language name

Chronic venous disease and diabetic microangiopathy: pathophysiology and commonalities

Original language description

Chronic venous disease and diabetes mellitus are highly prevalent and debilitating conditions affecting millions of individuals globally. Although these conditions are typically considered as separate entities, they often co-exist which may be important in both understanding their pathophysiology and determining the best treatment strategy. Diabetes mellitus is twice as common in patients with chronic venous disease compared with the general population. Notably, a large proportion of patients with diabetes mellitus present with venous disorders, although this is often overlooked. The etiology of chronic venous disease is multifactorial, involving hemodynamic, genetic, and environmental factors which result in changes to the venous endothelium and structural wall as well as inflammation. Inflammation, endothelial dysfunction and hyperfiltration or leakage, are commonly observed in diabetes mellitus and cause various diabetic microvascular complications. Both diseases are also influenced by the increased expression of adhesion molecules, chemokines, and cytokines, and are characterized by the presence of vessel hypertension. Consequently, despite differences in etiology, the pathophysiology of both chronic venous disease and diabetic microangiopathy appears to be driven by endothelial dysfunction and inflammation. Treatment strategies should take the co-existence of chronic venous disease and diabetic microangiopathy into account. Compression therapy is recommended in inflammatory conditions that have an edema component as seen in both chronic venous disease and diabetes mellitus. Lifestyle changes like weight loss and exercise, will improve metabolic state and lower inflammation and should be promoted in these patients. Additionally, both patient populations may benefit from venoactive drugs. (Cite this article as: Gastaldi G, Pannier F, Roztocil K, Lugli M, Mansilha A, Haller H, et al. Chronic venous disease and diabetic microangiopathy: pathophysiology and commonalities. Int Angiol 2021;40:457-69. DOI: 10.23736/S0392-9590.21.04664-2)

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International angiology

ISSN

0392-9590

e-ISSN

—

Volume of the periodical

40

Issue of the periodical within the volume

6

Country of publishing house

IT - ITALY

Number of pages

13

Pages from-to

457-469

UT code for WoS article

000727449200002

EID of the result in the Scopus database

2-s2.0-85121823089