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Antibody-Mediated Rejection of Renal Allografts: Diagnostic Pitfalls and Challenges

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00082263" target="_blank" >RIV/00023001:_____/21:00082263 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/21:10441341

  • Result on the web

    <a href="https://www.biomed.cas.cz/physiolres/pdf/2021/70_S551.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2021/70_S551.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.33549/physiolres.934801" target="_blank" >10.33549/physiolres.934801</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Antibody-Mediated Rejection of Renal Allografts: Diagnostic Pitfalls and Challenges

  • Original language description

    Antibody-mediated rejection (ABMR) is a major obstacle to the long-term success in kidney transplantation. Diagnosis of ABMR is determined according to the internationally recognized Banff criteria. However, a significant proportion of patients does not meet all the defined criteria, and the outcome of such cases remains poorly understood. The histology of ABMR frequently lacks sensitivity and specificity. More importantly, mixed forms of ABMR and T cell-mediated rejection as well as findings of nonspecific injury are common in clinical settings. Donor-specific anti-HLA antibodies (DSA) are detectable only in half of the ABMR cases by histology. Prognostic role of non-HLA antibodies against various endothelial proteins has been discussed. Antibody independent NK cell activation reflecting killer-cells&apos; inhibitory receptor incompatibility is suggested in microvascular inflammation in DSA negative patients. Molecular assessment of ABMR has been prioritized to overcome high interobserver variability and improve diagnostics in mixed forms of rejections and in DSA negative cases. Finally, donor-derived cell-free DNA detected in a recipient&apos;s peripheral blood sample has been proposed as a noninvasive marker for diagnosis of graft rejection, and thus might serve as a liquid biopsy in the near future. Despite all achievements, diagnosing ABMR in kidney allografts remains to be a challenge in a significant number of cases.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30213 - Transplantation

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological research

  • ISSN

    0862-8408

  • e-ISSN

  • Volume of the periodical

    70

  • Issue of the periodical within the volume

    Supplement 4

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    15

  • Pages from-to

    "S551"-"S565"

  • UT code for WoS article

    000768842600009

  • EID of the result in the Scopus database

    2-s2.0-85125110918