Antibody-Mediated Rejection of Renal Allografts: Diagnostic Pitfalls and Challenges
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00082263" target="_blank" >RIV/00023001:_____/21:00082263 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10441341
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2021/70_S551.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2021/70_S551.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934801" target="_blank" >10.33549/physiolres.934801</a>
Alternative languages
Result language
angličtina
Original language name
Antibody-Mediated Rejection of Renal Allografts: Diagnostic Pitfalls and Challenges
Original language description
Antibody-mediated rejection (ABMR) is a major obstacle to the long-term success in kidney transplantation. Diagnosis of ABMR is determined according to the internationally recognized Banff criteria. However, a significant proportion of patients does not meet all the defined criteria, and the outcome of such cases remains poorly understood. The histology of ABMR frequently lacks sensitivity and specificity. More importantly, mixed forms of ABMR and T cell-mediated rejection as well as findings of nonspecific injury are common in clinical settings. Donor-specific anti-HLA antibodies (DSA) are detectable only in half of the ABMR cases by histology. Prognostic role of non-HLA antibodies against various endothelial proteins has been discussed. Antibody independent NK cell activation reflecting killer-cells' inhibitory receptor incompatibility is suggested in microvascular inflammation in DSA negative patients. Molecular assessment of ABMR has been prioritized to overcome high interobserver variability and improve diagnostics in mixed forms of rejections and in DSA negative cases. Finally, donor-derived cell-free DNA detected in a recipient's peripheral blood sample has been proposed as a noninvasive marker for diagnosis of graft rejection, and thus might serve as a liquid biopsy in the near future. Despite all achievements, diagnosing ABMR in kidney allografts remains to be a challenge in a significant number of cases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
70
Issue of the periodical within the volume
Supplement 4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
15
Pages from-to
"S551"-"S565"
UT code for WoS article
000768842600009
EID of the result in the Scopus database
2-s2.0-85125110918