Postprandial Glucose Excursions in Asian Versus Non-Asian Patients with Type 2 Diabetes: A Post Hoc Analysis of Baseline Data from Phase 3 Randomised Controlled Trials of IDegAsp

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00082332" target="_blank" >RIV/00023001:_____/22:00082332 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/content/pdf/10.1007/s13300-021-01196-7.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s13300-021-01196-7.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13300-021-01196-7" target="_blank" >10.1007/s13300-021-01196-7</a>

Result language

angličtina

Original language name

Postprandial Glucose Excursions in Asian Versus Non-Asian Patients with Type 2 Diabetes: A Post Hoc Analysis of Baseline Data from Phase 3 Randomised Controlled Trials of IDegAsp

Original language description

Introduction Increased postprandial glucose (PPG) is associated with high glycated haemoglobin levels and is an independent risk factor for cardiovascular diseases. The aim of this study was to compare PPG increments in Asian versus non-Asian adults with type 2 diabetes (T2D), who were insulin-naive or insulin-experienced, from the phase 3 insulin degludec/insulin aspart (IDegAsp) clinical trials. Methods This was a post hoc analysis of data from 13 phase 3, randomised, parallel-group, open-label IDegAsp trials in patients with T2D. The pooled baseline clinical data were analysed for insulin-naive and insulin-experienced groups; and each group was split into subgroups of Asian and non-Asian patients, respectively, and analysed accordingly. Baseline self-monitored blood glucose (SMBG) values at breakfast, lunch and the evening meal (before and 90 min after each meal) were used to assess PPG increments. The estimated differences in baseline SMBG increment between the Asian and non-Asian subgroups were analysed. Results Clinical data from 4750 participants (insulin-naive, n = 1495; insulin-experienced, n = 3255) were evaluated. In the insulin-naive group, the postprandial SMBG increment was significantly greater in the Asian versus the non-Asian subgroup at breakfast (estimated difference 28.67 mg/dL, 95% confidence interval [CI] 18.35, 38.99; p &lt; 0.0001), lunch (17.34 mg/dL, 95% CI 6.47, 28.21; p = 0.0018) and the evening meal (16.19 mg/dL, 95% CI 5.04, 27.34; p = 0.0045). In the insulin-experienced group, the postprandial SMBG increment was significantly greater in the Asian versus non-Asian subgroup at breakfast (estimated difference 13.81 mg/dL, 95% CI 9.19, 18.44; p &lt; 0.0001) and lunch (29.18 mg/dL, 95% CI 24.22, 34.14; p &lt; 0.0001), but not significantly different at the evening meal. Conclusion In this post hoc analysis, baseline PPG increments were significantly greater in Asian participants with T2D than in their non-Asian counterparts at all mealtimes, with the exception of the evening meal in insulin-experienced participants. Asian adults with T2D may benefit from the use of regimens that control PPG excursions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diabetes therapy

ISSN

1869-6953

e-ISSN

1869-6961

Volume of the periodical

13

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

13

Pages from-to

311-323

UT code for WoS article

000744376800001

EID of the result in the Scopus database

2-s2.0-85123106304