Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00082532" target="_blank" >RIV/00023001:_____/22:00082532 - isvavai.cz</a>
Result on the web
<a href="https://journals.biologists.com/jcs/article/135/5/jcs258901/273436/Apolipoprotein-A1-deficiency-in-mice-primes-bone" target="_blank" >https://journals.biologists.com/jcs/article/135/5/jcs258901/273436/Apolipoprotein-A1-deficiency-in-mice-primes-bone</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/jcs.258901" target="_blank" >10.1242/jcs.258901</a>
Alternative languages
Result language
angličtina
Original language name
Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis
Original language description
The bone marrow has emerged as a potentially important target in cardiovascular disease as it generates all leukocytes involved in atherogenesis. In the current study, we evaluated whether a change in bone marrow functionality underlies the increased atherosclerosis susceptibility associated with high-density lipoprotein (HDL) deficiency. We found that HDL deficiency in mice due to the genetic lack of hepatocyte-derived apolipoprotein A1 (APOA1) was associated with an increase in the Lin(-)Sca-1(+)Kit(+) (LSK) bone marrow stem cell population and lymphoid-primed multipotent progenitor numbers, which translated into a higher production and systemic flux of T cell subsets. In accordance with APOA1 deficiency-associated priming of stem cells to increase T lymphocyte production, atherogenic diet-fed low-density lipoprotein receptor knockout mice transplanted with bone marrow from APOA1-knockout mice displayed marked lymphocytosis as compared to wild-type bone marrow recipients. However, atherosclerotic lesion sizes and collagen contents were similar in the two groups of bone marrow recipients. In conclusion, systemic lack of APOA1 primes bone marrow stem cells for T cell lymphopoiesis. Our data provide novel evidence for a regulatory role of HDL in bone marrow functioning in normolipidemic mice.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of cell science
ISSN
0021-9533
e-ISSN
1477-9137
Volume of the periodical
135
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
"Art. no. jcs258901"
UT code for WoS article
000783839400020
EID of the result in the Scopus database
2-s2.0-85121958430