Galectin-3 as an independent prognostic factor after heart transplantation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00082650" target="_blank" >RIV/00023001:_____/22:00082650 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/22:43922791
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/ctr.14592" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/ctr.14592</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ctr.14592" target="_blank" >10.1111/ctr.14592</a>
Alternative languages
Result language
angličtina
Original language name
Galectin-3 as an independent prognostic factor after heart transplantation
Original language description
Background Galectin-3 (GAL3) is linked to the prognosis of patients with heart failure and after heart transplantation (HTx). We assessed the prognostic role of GAL3 in a long-term follow-up after HTx. Methods HTx patients (N = 121) were evaluated in a single-center, noninterventional, prospective, observational study. The median follow-up was 96 months (2942 days, interquartile range (IQR) 2408-3264 days), and 40 patients died. GAL3 was measured before HTx, +10 days after HTx, and during the first posttransplant year. Survival analysis (all-cause mortality) was performed with adjustments for clinical and laboratory variables. Results The median pretransplant GAL3 level was 18.0 mu g/L (IQR 14.0-25.9), and higher values were associated with older age, worse kidney function, left ventricular assist device use before HTx, a higher IMPACT score, and mortality. Increased pretransplant GAL3 predicted shorter survival time (HR 2.05, 95% CI 1.09-3.85, p < .05). Similar prognostic power had GAL3 on the 10th posttransplant day (HR 2.03, 95% CI 1.08-3.82, p < .05). GAL3 was an independent predictor of death after adjustment for clinical variables (age, infection, diabetes, smoking, IMPACT score, and troponin). Conclusions GAL3 was significantly associated with all-cause mortality after adjusting for clinical and laboratory variables and may serve as an additional prognostic biomarker.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical transplantation
ISSN
0902-0063
e-ISSN
1399-0012
Volume of the periodical
36
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
"Art. no e14592"
UT code for WoS article
000749666300001
EID of the result in the Scopus database
2-s2.0-85123718888