Increased vitamin B6 turnover is associated with greater mortality risk in the general US population: A prospective biomarker study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00082693" target="_blank" >RIV/00023001:_____/22:00082693 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/22:43923579 RIV/00216208:11120/22:43923579

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S026156142200142X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S026156142200142X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clnu.2022.04.023" target="_blank" >10.1016/j.clnu.2022.04.023</a>

Result language

angličtina

Original language name

Increased vitamin B6 turnover is associated with greater mortality risk in the general US population: A prospective biomarker study

Original language description

BACKGROUND &amp; AIMS: Vitamin B6 status and mortality risk are inversely associated in different patient groups, while prospective studies in the general population are lacking. Here, for the first time, we evaluated the association between biomarkers of vitamin B6 status and mortality risk in a large population-based study. METHODS: The vitamin B6 vitamers pyridoxal-5&apos;-phosphat (PLP) and 4-pyridoxic acid (4-PA) were measured by high-performance liquid chromatography in the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2010. Participants&apos; vital status and causes of death were recorded until December 2015. Multivariable Cox regression analyses were carried out to estimate Hazard Ratios (HRs) and 95% confidence intervals (CIs) of mortality across quintiles of PLP, 4-PA, and the ratio of 4-PA and PLP. RESULTS: Out of 15,304 study participants aged between 20 and 85 years at baseline, 1666 (7.7%) died during a median follow-up time of 7.8 years. An inverse association between PLP and mortality was found in a multivariable model adjusted for socioeconomic and lifestyle factors but became statistically non-significant upon adjustment for routine biomarkers (C-reactive protein, creatinine, albumin, and alkaline phosphatase). There was a significant linear trend for a positive association between 4-PA levels and mortality risk in the fully adjusted regression model, although a comparison of extreme quintiles (quintile 5 vs. quintile 1) did not show a significant difference (HR(Q5vs.Q1) (95% CI): 1.19 (0.93, 1.51), p(linear trend) = 0.02). A positive association between the 4-PA/PLP ratio and all-cause mortality was observed in the multivariable model, with an HRs(Q5vs.Q1) of 1.45 (95% CI: 1.14, 1.85; p(linear trend)&lt;0.0001). There were no significant associations between the biomarkers and cardiovascular or cancer mortality. The association between 4-PA/PLP and mortality risk was heterogeneous across age groups, and only statistically significant among participants older than 65 years at baseline (HR(Q5vs.Q1) (95% CI): 1.72 (1.29, 2.29), p(linear trend)&lt;0.0001). In this group, 4-PA/PLP was also associated with cancer mortality, with an HR (Q5vs.Q1) of 2.16 (1.20, 3.90), p(linear trend) = 0.02). CONCLUSION: Increased vitamin B6 turnover, as indicated by a higher 4-PA/PLP ratio, was associated with all-cause and cancer mortality among the older U.S. general population. Intervention trials are needed to assess whether older individuals with a high 4-PA/PLP ratio would benefit from increased vitamin B6 intake.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30308 - Nutrition, Dietetics

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical nutrition

ISSN

0261-5614

e-ISSN

1532-1983

Volume of the periodical

41

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

1343-1356

UT code for WoS article

000807402400002

EID of the result in the Scopus database

2-s2.0-85130346824