Sepsis affects kidney graft function and one-year mortality of the recipients in contrast with systemic inflammatory response

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083101" target="_blank" >RIV/00023001:_____/22:00083101 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/22:10446251

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fmed.2022.923524/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fmed.2022.923524/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmed.2022.923524" target="_blank" >10.3389/fmed.2022.923524</a>

Result language

angličtina

Original language name

Sepsis affects kidney graft function and one-year mortality of the recipients in contrast with systemic inflammatory response

Original language description

Background: Infections remain a major cause of morbidity and mortality after kidney transplantation. The aim of our study was to determine the effect of sepsis on kidney graft function and recipient mortality. Methods: A prospective, observational, single-center study was performed. Selected clinical and biochemical parameters were recorded and compared between an experimental group (with sepsis, n = 34) and a control group (with systemic inflammatory response syndrome, n = 31) comprising kidney allograft recipients. Results: Sepsis worsened both patient (HR = 14.77, p = 0.007) and graft survival (HR = 15.07, p = 0.007). Overall one-year mortality was associated with age (HR = 1.08, p = 0.048), APACHE II score (HR = 1.13, p = 0.035), and combination immunosuppression therapy (HR = 0.1, p = 0.006), while graft survival was associated with APACHE II (HR = 1.25, p = 0.004) and immunosuppression. In sepsis patients, mortality correlated with the maximal dose of noradrenalin (HR = 100.96, p = 0.008), fungal infection (HR = 5.64, p = 0.024), SAPS II score (HR = 1.06, p = 0.033), and mechanical ventilation (HR = 5.97, p = 0.033), while graft survival was influenced by renal replacement therapy (HR = 21.16, p = 0.005), APACHE II (HR = 1.19, p = 0.035), and duration of mechanical ventilation (HR = 1.01, p = 0.015). Conclusion: In contrast with systemic inflammatory response syndrome, septic kidney allograft injury is associated with early graft loss and may represent a significant risk of mortality.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30213 - Transplantation

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in medicine [online]

ISSN

2296-858X

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

Jul 29

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

923524

UT code for WoS article

000861301700001

EID of the result in the Scopus database

2-s2.0-85135929581