Waiting time for second kidney transplantation and mortality
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083309" target="_blank" >RIV/00023001:_____/22:00083309 - isvavai.cz</a>
Result on the web
<a href="https://cjasn.asnjournals.org/content/clinjasn/17/1/90.full.pdf?with-ds=yes" target="_blank" >https://cjasn.asnjournals.org/content/clinjasn/17/1/90.full.pdf?with-ds=yes</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2215/CJN.07620621" target="_blank" >10.2215/CJN.07620621</a>
Alternative languages
Result language
angličtina
Original language name
Waiting time for second kidney transplantation and mortality
Original language description
Background and objectives The median kidney transplant half-life is 10-15 years. Because of the scarcity of donor organs and immunologic sensitization of candidates for retransplantation, there is a need for quantitative information on if and when a second transplantation is no longer associated with a lower risk of mortality compared with waitlisted patients treated by dialysis. Therefore, we investigated the association of time on waiting list with patient survival in patients who received a second transplantation versus remaining on the waiting list. Design, setting, participants, & measurements In this retrospective study using target trial emulation, we analyzed data of 2346 patients from the Austrian Dialysis and Transplant Registry and Eurotransplant with a failed first graft, aged over 18 years, and waitlisted for a second kidney transplantation in Austria during the years 1980-2019. The differences in restricted mean survival time and hazard ratios for all-cause mortality comparing the treatment strategies "retransplant" versus" remain waitlisted with maintenance dialysis" are reported for different waiting times after first graft loss. Results Second kidney transplantation showed a longer restricted mean survival time at 10 years of follow-up compared with remaining on the waiting list (5.8 life months gained; 95% confidence interval, 0.9 to 11.1). This survival difference was diminished in patients with longer waiting time after loss of the first allograft; restricted mean survival time differences at 10 years were 8.0 (95% confidence interval, 1.9 to 14.0) and 0.1 life months gained (95%confidence interval,214.3 to 15.2) for patients with waiting time for retransplantation of < 1 and 8 years, respectively. Conclusions Second kidney transplant is associated with patient survival compared with remaining waitlisted and treatment by dialysis, but the survival difference diminishes with longer waiting time.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical journal of the American Society of Nephrology
ISSN
1555-9041
e-ISSN
1555-905X
Volume of the periodical
17
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
90-97
UT code for WoS article
000737125800001
EID of the result in the Scopus database
2-s2.0-85123299803