Tuberculosis dissemination in kidney transplant recipient treated with anti-CD40 monoclonal antibody: a case report

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083317" target="_blank" >RIV/00023001:_____/22:00083317 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/22:10446701 RIV/00064190:_____/22:N0000016

Result on the web

<a href="https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-022-02916-2" target="_blank" >https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-022-02916-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12882-022-02916-2" target="_blank" >10.1186/s12882-022-02916-2</a>

Result language

angličtina

Original language name

Tuberculosis dissemination in kidney transplant recipient treated with anti-CD40 monoclonal antibody: a case report

Original language description

Background Tuberculosis (TBC) in solid organ transplant recipients represents a severe complication. The incidence among transplant recipients is higher than in the general population, and the diagnosis and treatment remain challenging. We present a case of active disseminated tuberculosis in a kidney transplant recipient treated with an anti-CD40 monoclonal antibody, who had been previously exposed to an active form of the disease, but latent tuberculosis (LTBI) was repeatedly ruled out prior to transplantation. To the best of our knowledge, no other case has been reported in a patient treated with the anti-CD40 monoclonal antibody. Case presentation A 49-year-old patient, 1.5 years after primary kidney transplantation, presented with vocal cord problems, a dry irritating cough, and a sore throat. A detailed investigation, including a high-resolution chest CT scan, revealed the diagnosis of disseminated tuberculosis. The antituberculosis treatment consisting of rifampicin, isoniazid, pyrazinamide, and ethambutol was started immediately. The patient&apos;s condition became complicated by relapsing diarrhoea. The colonoscopy revealed a circular stenosis above Bauhin&apos;s valve. Microscopical findings showed active colitis and vaguely formed collections of epithelioid macrophages without fully developed caseous granulomas and were consistent with the clinical diagnosis of tuberculosis. The antituberculosis treatment was subsequently enhanced by moxifloxacin and led to a great improvement in the patient&apos;s condition. Conclusion In this case, false negativity of interferon-gamma release assays and possibly higher risk for intracellular infections in patients on costimulatory signal blockers are discussed.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30217 - Urology and nephrology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC nephrology [online]

ISSN

1471-2369

e-ISSN

1471-2369

Volume of the periodical

23

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

"art. no. 290"

UT code for WoS article

000842034300001

EID of the result in the Scopus database

2-s2.0-85136961989