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Adrenal venous sampling could be omitted before surgery inpPatients with Conn's adenoma confirmed by computed tomography and higher normal aldosterone concentration after saline infusion test

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083400" target="_blank" >RIV/00023001:_____/22:00083400 - isvavai.cz</a>

  • Result on the web

    <a href="http://file:///C:/Users/mati/AppData/Local/Temp/diagnostics-12-01718.pdf" target="_blank" >http://file:///C:/Users/mati/AppData/Local/Temp/diagnostics-12-01718.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/diagnostics12071718" target="_blank" >10.3390/diagnostics12071718</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Adrenal venous sampling could be omitted before surgery inpPatients with Conn's adenoma confirmed by computed tomography and higher normal aldosterone concentration after saline infusion test

  • Original language description

    Purpose: Adrenal venous sampling (AVS) performed to distinguish unilateral and bilateral primary aldosteronism (PA) is invasive and poorly standardized. This study aimed to identify non-invasive characteristics that can select the patients with unilateral PA who could bypass AVS before surgery. Methods: A single-center study collected a total of 450 patients with PA. Development and validation cohorts included 242 and 208 patients. The AVS was successful in 150 and 138 patients from the cohorts, and the unilateral PA was found in 96 and 94 patients, respectively. Clinical factors independently associated with lateralized AVS in multivariable logistic regression were used to construct a unilateral PA prediction score (SCORE). Results: The proposed SCORE was calculated as a sum of the prevalence of adrenal nodule on computed tomography (2 points) and plasma/serum aldosterone concentration &gt;= 165 ng/L after the saline infusion test (SIT) (1 point). Importantly, the SCORE = 3 points identified 48% of unilateral PA patients with a specificity of 100% in the development cohort. The zero rate of false-positive classifications was preserved with the same cut-off value in the validation cohort. Conclusions: AVS could be omitted before surgery in patients with typical Conn &apos; s adenoma provided the aldosterone concentration &gt;= 165 ng/L after the SIT.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Diagnostics

  • ISSN

    2075-4418

  • e-ISSN

    2075-4418

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    14

  • Pages from-to

    "art. no. 1718"

  • UT code for WoS article

    000833205000001

  • EID of the result in the Scopus database

    2-s2.0-85137377745