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Acute efficacy of contiguous versus temporally discontiguous point-by-point radiofrequency pulmonary vein isolation in patients with paroxysmal atrial fibrillation : a randomized study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083454" target="_blank" >RIV/00023001:_____/22:00083454 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064173:_____/22:43922755 RIV/00216208:11110/22:10436255 RIV/00216208:11120/22:43922755

  • Result on the web

    <a href="https://link.springer.com/content/pdf/10.1007/s10840-021-01113-9.pdf?pdf=button" target="_blank" >https://link.springer.com/content/pdf/10.1007/s10840-021-01113-9.pdf?pdf=button</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s10840-021-01113-9" target="_blank" >10.1007/s10840-021-01113-9</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Acute efficacy of contiguous versus temporally discontiguous point-by-point radiofrequency pulmonary vein isolation in patients with paroxysmal atrial fibrillation : a randomized study

  • Original language description

    Purpose Durable pulmonary vein (PV) isolation (PVI) determines the clinical success of catheter ablation for atrial fibrillation. In this randomized study, we investigated whether the temporally discontiguous deployment of ablation lesions adversely affected the acute efficacy of PVI. Methods Thirty-six consecutive patients with drug-refractory paroxysmal atrial fibrillation (aged 59 +/- 11, 58% males) were randomized 1:1 to either discontiguous (D-PVI) or contiguous (C-PVI) encircling radiofrequency (RF) lesions around ipsilateral PVs. A contact force-sensing catheter was used targeting a final interlesion distance &lt; 6 mm and the ablation index of 400-450 (anterior wall) and 300-350 (posterior wall). The study endpoint was defined as failure of first-pass PVI or acute PV reconnection during a waiting time (&gt; 30 min) followed by adenosine challenge. Results The total RF time, number of RF lesions, and mean interlesion distance were comparable in both groups. Total endpoint rates were 1/36 (3%) in the D-PVI vs 4/36 (11%) in the C-PVI groups; P = 0.34 for superiority, P = 0.008 for non-inferiority. Adenosine-induced reconnection of right PVs was the only endpoint in the D-PVI group. In the C-PVI group, first-pass PVI failed in 2 right PVs and spontaneous reconnection occurred in 2 other circles (left and right PVs). Conclusion Temporally discontiguous deployment of RF lesions is not associated with lower procedural PVI efficacy when strict criteria for interlesion distance and ablation index are applied. The development of local edema around each ablation site does not prevent effective RF lesion formation at adjacent positions.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of interventional cardiac electrophysiology: an international journal of arrhythmias and pacing

  • ISSN

    1383-875X

  • e-ISSN

    1572-8595

  • Volume of the periodical

    64

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    7

  • Pages from-to

    661-667

  • UT code for WoS article

    000739277700001

  • EID of the result in the Scopus database

    2-s2.0-85122309047