Central Disorders of Hypersomnolence: Association with Fatigue, Depression and Sleep Inertia Prevailing in Women

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083482" target="_blank" >RIV/00023001:_____/22:00083482 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/22:10451333 RIV/00216208:11110/22:10451333

Result on the web

<a href="https://www.mdpi.com/2076-3425/12/11/1491" target="_blank" >https://www.mdpi.com/2076-3425/12/11/1491</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/brainsci12111491" target="_blank" >10.3390/brainsci12111491</a>

Result language

angličtina

Original language name

Central Disorders of Hypersomnolence: Association with Fatigue, Depression and Sleep Inertia Prevailing in Women

Original language description

Fatigue, depression, and sleep inertia are frequently underdiagnosed manifestations in narcolepsy and idiopathic hypersomnia. Our cross-sectional study design included diagnostic interview accompanied by assessment instruments and aimed to explore how these factors influence disease severity as well as to elucidate any sex predisposition. One hundred and forty-eight subjects (female 63%) were divided into narcolepsy type 1 (NT1; n = 87, female = 61%), narcolepsy type 2 (NT2; n = 22, female = 59%), and idiopathic hypersomnia (IH; n = 39, female = 69%). All subjects completed a set of questionnaires: Epworth Sleepiness Scale (ESS), Hospital Anxiety and Depression Scales (HADS), Fatigue Severity Scale (FSS), and Sleep Inertia Questionnaire (SIQ). In narcoleptic subjects, questionnaire data were correlated with the Narcolepsy Severity Scale (NSS), and in subjects with idiopathic hypersomnia, with the Idiopathic Hypersomnia Severity Scale (IHSS). The highest correlation in narcoleptic subjects was found between NSS and ESS (r = 0.658; p &lt; 0.0001), as well as FSS (r = 0.506; p &lt; 0.0001), while in subjects with idiopathic hypersomnia, the most prominent positive correlations were found between IHSS and SIQ (r = 0.894; p &lt; 0.0001), FSS (r = 0.812; p &lt; 0.0001), HADS depression scale (r = 0.649; p = 0.0005), and HADS anxiety scale (r = 0.528; p &lt; 0.0001). ESS showed an analogic correlation with disease severity (r = 0.606; p &lt; 0.0001). HADS anxiety and depression scores were higher in females (p &lt; 0.05 and p &lt; 0.01), with similar results for FSS and SIQ scales (p &lt; 0.05 for both), and a trend toward higher ESS values in females (p = 0.057). Our study illustrates that more attention should be focused on pathophysiological mechanisms and associations of fatigue, depression, as well as sleep inertia in these diseases; they influence the course of both illnesses, particularly in women.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NU20-04-00088" target="_blank" >NU20-04-00088: Gut microbiome and autoimmune mechanisms in patients with central hypersomnia</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain sciences

ISSN

2076-3425

e-ISSN

2076-3425

Volume of the periodical

12

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

12

Pages from-to

"art. no. 1491"

UT code for WoS article

000883491000001

EID of the result in the Scopus database

2-s2.0-85141748122