A multi-institutional study of renal outcomes and renal-related pregnancy outcomes in uterus transplant recipients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083675" target="_blank" >RIV/00023001:_____/22:00083675 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10445390 RIV/00216208:11130/22:10445390
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S160061352300062X?token=F6D087E7D289E8FDB84AB79159AD736F6DD4AED209F27579598DFA0DF3174E4968E32078E79F8E82C1CA85EBBEEAA926&originRegion=eu-west-1&originCreation=20230306134937" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S160061352300062X?token=F6D087E7D289E8FDB84AB79159AD736F6DD4AED209F27579598DFA0DF3174E4968E32078E79F8E82C1CA85EBBEEAA926&originRegion=eu-west-1&originCreation=20230306134937</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ajt.17149" target="_blank" >10.1111/ajt.17149</a>
Alternative languages
Result language
angličtina
Original language name
A multi-institutional study of renal outcomes and renal-related pregnancy outcomes in uterus transplant recipients
Original language description
Uterus transplantation (UTx) is an effective treatment option for uterine factor infertility. However, the need for immunosuppression and congenital renal anomalies that coexist with uterine agenesis in about 30% of women with Mayer-Rokitansky-Kuster-Hauser syndrome create a risk for renal dysfunction. We therefore examined renal function trajectory and related pregnancy complications in an international cohort of 18 UTx recipients from September 2016-February 2020 who had at least one live birth. All UTx recipients had a diminution in their renal function that was apparent starting at 30 days posttransplant and in half the reduction in eGFR was at least 20%; the decrease in eGFR persisted into the early post-partum period. Half met criteria for Stage 1 acute kidney injury (AKI) as defined by the AKI Network criteria during their pregnancy. Overall, 28% of UTx recipients developed pre-eclampsia. eGFR was lower at embryo transfer and throughout pregnancy among those who developed pre-eclampsia, reaching statistical significance at week 16 of pregnancy. This effect was independent of tacrolimus levels. Mean eGFR remained significantly lower in the first 1-3 months after delivery. In the subgroup who reached 12 months of postpartum follow up and had a graft hysterectomy (n = 4), there was no longer a statistical difference in eGFR (pretransplant 106.7 ml/m +/- 17.7 vs. 12 mos postpartum 92.6 ml/m +/- 21.7, p = .13) but the number was small. Further study is required to delineate long term renal risks for UTx recipients, improve patient selection, and make decisions regarding a second pregnancy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American journal of transplantation
ISSN
1600-6135
e-ISSN
1600-6143
Volume of the periodical
22
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
3101-3110
UT code for WoS article
000923882300013
EID of the result in the Scopus database
2-s2.0-85134546742