Effects of renal nerves and plasma epoxyeicosatrienoic acids on blood pressure, renal hemodynamics and excretion in spontaneously hypertensive rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083686" target="_blank" >RIV/00023001:_____/22:00083686 - isvavai.cz</a>

Result on the web

<a href="https://jpp.krakow.pl/journal/archive/04_22/pdf/10.26402/jpp.2022.2.12.pdf" target="_blank" >https://jpp.krakow.pl/journal/archive/04_22/pdf/10.26402/jpp.2022.2.12.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.26402/jpp.2022.2.12" target="_blank" >10.26402/jpp.2022.2.12</a>

Result language

angličtina

Original language name

Effects of renal nerves and plasma epoxyeicosatrienoic acids on blood pressure, renal hemodynamics and excretion in spontaneously hypertensive rats

Original language description

Spontaneously hypertensive rats (SHR) display deficiency of epoxyeicosatrienoic acids (EETs). Their possible interaction with renal sympathetic nerves remains unexplored; synthesis of EET- A [disodium (S)-2-( 13-(3-pentyl)ureido)-tridec-8(Z)-enamido)succinate], a stable 14,15-EET analog, helps clarify the issue. In anesthetized SHR, untreated or pretreated with EET-A, we assessed early responses of blood pressure (MAP), renal hemodynamics and excretion, and indices of nitric oxide (NO) activity, to bilateral noninvasive renal denervation (DNX). DNX significantly decreased MAP, with or without EET-A pretreatment. Renal perfusion decreased in EET-A treated but not in control rats. After EET-A pretreatment DNX decreased renal excretion of sodium and total solutes, compared to increasing tendency in untreated rats. In EET-A treated but not in untreated SHR denervation reduced the excretion of NO metabolites. Antihypertensive action of EET-A in anesthetized SHR was not clearly dependent on renal nerve activity. On the other hand, DNX unmasked the unexpected effect of EET-A to lower renal perfusion. The mechanism of this novel finding is unclear, as is also the simultaneous post-denervation decrease in renal excretion, again, observed only under EET-A treatment. Possibly, the decrease was secondary to falling MAP and renal perfusion. Increased renal excretion of nitric oxide metabolites under EETs elevation strongly suggests facilitation of NO release; the effect that was observed only with intact renal nerve activity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of physiology and pharmacology

ISSN

0867-5910

e-ISSN

1899-1505

Volume of the periodical

73

Issue of the periodical within the volume

2

Country of publishing house

PL - POLAND

Number of pages

9

Pages from-to

287-295

UT code for WoS article

000918020400001

EID of the result in the Scopus database

2-s2.0-85139134133