Fibronectin in hyperglycaemia and its potential use in the treatment of diabetic foot ulcers: a review

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00083815" target="_blank" >RIV/00023001:_____/23:00083815 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/23:10451967 RIV/00216208:11120/23:43924465 RIV/00216208:11140/23:10451967 RIV/00216208:11150/23:10451967
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.13997" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.13997</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/iwj.13997" target="_blank" >10.1111/iwj.13997</a>

Result language
angličtina
Original language name
Fibronectin in hyperglycaemia and its potential use in the treatment of diabetic foot ulcers: a review
Original language description
Metabolism of fibronectin, the protein that plays a key role in the healing of wounds, is changed in the patients with diabetes mellitus. Fibronectin can interact with other proteins and proteoglycans and organise them to form the extracellular matrix, the basis of the granulation tissue in healing wounds. However, diabetic foot ulcers (DFUs) suffer from inadequate deposition of this protein. Degradation prevails over fibronectin synthesis in the proteolytic inflammatory environment in the ulcers. Because of the lack of fibronectin in the wound bed, the assembly of the extracellular matrix and the deposition of the granulation tissue cannot be started. A number of methods have been designed that prevents fibronectin degradation, replace lacking fibronectin or support its formation in non-healing wounds in animal models of diabetes. The aim of this article is to review the metabolism of fibronectin in DFUs and to emphasise that it would be useful to pay more attention to fibronectin matrix assembly in the ulcers when laboratory methods are translated to clinical practice.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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