M1/M2 macrophages and their overlaps-myth or reality?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084120" target="_blank" >RIV/00023001:_____/23:00084120 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/23:10466299 RIV/00216208:11110/23:10466299 RIV/00064203:_____/23:10466299

Result on the web

<a href="https://portlandpress.com/clinsci/article/137/15/1067/233341/M1-M2-macrophages-and-their-overlaps-myth-or" target="_blank" >https://portlandpress.com/clinsci/article/137/15/1067/233341/M1-M2-macrophages-and-their-overlaps-myth-or</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1042/CS20220531" target="_blank" >10.1042/CS20220531</a>

Result language

angličtina

Original language name

M1/M2 macrophages and their overlaps-myth or reality?

Original language description

Macrophages represent heterogeneous cell population with important roles in defence mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations adopt distinct activation states. M1 and M2 macrophages are two polarized forms of mononuclear phagocyte in vitro differentiation with distinct phenotypic patterns and functional properties, but in vivo, there is a wide range of different macrophage phenotypes in between depending on the microenvironment and natural signals they receive. In human infections, pathogens use different strategies to combat macrophages and these strategies include shaping the macrophage polarization towards one or another phenotype. Macrophages infiltrating the tumours can affect the patient&apos;s prognosis. M2 macrophages have been shown to promote tumour growth, while M1 macrophages provide both tumour-promoting and anti-tumour properties. In autoimmune diseases, both prolonged M1 activation, as well as altered M2 function can contribute to their onset and activity. In human atherosclerotic lesions, macrophages expressing both M1 and M2 profiles have been detected as one of the potential factors affecting occurrence of cardiovascular diseases. In allergic inflammation, T2 cytokines drive macrophage polarization towards M2 profiles, which promote airway inflammation and remodelling. M1 macrophages in transplantations seem to contribute to acute rejection, while M2 macrophages promote the fibrosis of the graft. The view of pro-inflammatory M1 macrophages and M2 macrophages suppressing inflammation seems to be an oversimplification because these cells exploit very high level of plasticity and represent a large scale of different immunophenotypes with overlapping properties. In this respect, it would be more precise to describe macrophages as M1-like and M2-like.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

<a href="/en/project/NU23J-08-00031" target="_blank" >NU23J-08-00031: Combinatorial treatment strategies to overcome immunotherapy resistance in soft tissue sarcomas</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical science

ISSN

0143-5221

e-ISSN

1470-8736

Volume of the periodical

137

Issue of the periodical within the volume

15

Country of publishing house

GB - UNITED KINGDOM

Number of pages

27

Pages from-to

1067-1093

UT code for WoS article

001046106300002

EID of the result in the Scopus database

2-s2.0-85166153408