Targeted left ventricular lead positioning to the site of latest activation in cardiac resynchronization therapy: a systematic review and meta-analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084244" target="_blank" >RIV/00023001:_____/23:00084244 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/23:10469463 RIV/00179906:_____/23:10469463 RIV/00023884:_____/23:00009580
Result on the web
<a href="https://academic.oup.com/europace/article/25/9/euad267/7268805?login=true" target="_blank" >https://academic.oup.com/europace/article/25/9/euad267/7268805?login=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/europace/euad267" target="_blank" >10.1093/europace/euad267</a>
Alternative languages
Result language
angličtina
Original language name
Targeted left ventricular lead positioning to the site of latest activation in cardiac resynchronization therapy: a systematic review and meta-analysis
Original language description
Aims Several studies have evaluated the use of electrically- or imaging-guided left ventricular (LV) lead placement in cardiac resynchronization therapy (CRT) recipients. We aimed to assess evidence for a guided strategy that targets LV lead position to the site of latest LV activation.Methods and results A systematic review and meta-analysis was performed for randomized controlled trials (RCTs) until March 2023 that evaluated electrically- or imaging-guided LV lead positioning on clinical and echocardiographic outcomes. The primary endpoint was a composite of all-cause mortality and heart failure hospitalization, and secondary endpoints were quality of life, 6-min walk test (6MWT), QRS duration, LV end-systolic volume, and LV ejection fraction. We included eight RCTs that comprised 1323 patients. Six RCTs compared guided strategy (n = 638) to routine (n = 468), and two RCTs compared different guiding strategies head-to-head: electrically- (n = 111) vs. imaging-guided (n = 106). Compared to routine, a guided strategy did not significantly reduce the risk of the primary endpoint after 12-24 (RR 0.83, 95% CI 0.52-1.33) months. A guided strategy was associated with slight improvement in 6MWT distance after 6 months of follow-up of absolute 18 (95% CI 6-30) m between groups, but not in remaining secondary endpoints. None of the secondary endpoints differed between the guided strategies.Conclusion In this study, a CRT implantation strategy that targets the latest LV activation did not improve survival or reduce heart failure hospitalizations. Graphical Abstract
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Europace
ISSN
1099-5129
e-ISSN
1532-2092
Volume of the periodical
25
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
"art. no. euad267"
UT code for WoS article
001067559800001
EID of the result in the Scopus database
—