The importance of sampling time in radionuclide measurement of glomerular filtration rate in adults using single blood sample

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084250" target="_blank" >RIV/00023001:_____/23:00084250 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10466821 RIV/00064165:_____/23:10466821

Result on the web

<a href="https://link.springer.com/article/10.1007/s40336-023-00583-3" target="_blank" >https://link.springer.com/article/10.1007/s40336-023-00583-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40336-023-00583-3" target="_blank" >10.1007/s40336-023-00583-3</a>

Result language

angličtina

Original language name

The importance of sampling time in radionuclide measurement of glomerular filtration rate in adults using single blood sample

Original language description

PurposeIn theory, radionuclide measurement of glomerular filtration rate (GFR) using bolus injection and a single blood sample results in GFR values close to the results of slope-intercept (SI) method using two or more blood samples, especially if the sample is collected at specific time. The aim of our study was to provide experimental validation of this assumption, to design the new single-sample methods potentially correcting for inadequate sampling time, and to validate them together with the method recommended by the British Nuclear Medicine Society (BNMS) guidelines.MethodsNew analytic and regression-based single-sample methods were developed using previously published concepts. In 373 patients, GFR measured by the new methods and by the method recommended by the BNMS guidelines was compared with the reference GFR measured by SI method using two blood samples. Prediction of the reference GFR was evaluated by cross-validation with all blood samples and with blood samples collected at time interval &amp; PLUSMN; 30 min around optimal sampling time.ResultsWith all 768 blood samples (regardless of sampling time), the method recommended by the BNMS guidelines performed significantly better than the new methods, predicting reference GFR with the mean absolute error (MAE) of 2.55 (versus 2.95-3.37) ml/min/1.73 m(2). In the subset of blood samples collected at time interval &amp; PLUSMN; 30 min around optimal sampling time derived from SI method (n = 247), performance of all methods was significantly improved. MAE was reduced to 1.18 (vs. 1.27-1.39) ml/min/1.73 m(2). Realistic estimate of optimal sampling time using creatinine prediction equation CKD-EPI (n = 235) resulted in MAE of 1.37 (vs. 1.53-1.76) ml/min/1.73 m(2).ConclusionThe study experimentally confirmed that collection of single blood sample near patient-specific optimal sampling time significantly improves accuracy of prediction of the reference SI GFR by all validated single-sample methods. The method recommended by the BNMS guidelines provided the best results with low prediction error that was further reduced by collecting blood sample at optimal sampling time. The new methods successfully corrected for small deviations from optimal sampling time.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30217 - Urology and nephrology

Project

<a href="/en/project/GA303%2F07%2F0950" target="_blank" >GA303/07/0950: Quantitative assessment of dynamic renal scintigraphy</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical and Translational Imaging

ISSN

2281-5872

e-ISSN

2281-7565

Volume of the periodical

11

Issue of the periodical within the volume

5

Country of publishing house

IT - ITALY

Number of pages

12

Pages from-to

493-504

UT code for WoS article

001043657600002

EID of the result in the Scopus database

2-s2.0-85166911253