Eosinophils-from cradle to grave
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084416" target="_blank" >RIV/00023001:_____/23:00084416 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10469070 RIV/00216208:11110/23:10469070 RIV/00064203:_____/23:10469070 RIV/00064190:_____/23:10001176
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.15884" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.15884</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/all.15884" target="_blank" >10.1111/all.15884</a>
Alternative languages
Result language
angličtina
Original language name
Eosinophils-from cradle to grave
Original language description
Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be classified into primary (clonal) and secondary (reactive) disorders and idiopathic (hyper)eosinophilic syndromes. Depending on the biological specimen, the eosinophil count in different body compartments may serve as a biomarker reflecting the underlying pathophysiology and/or activity of distinct diseases and as a therapy-driving (predictive) and monitoring tool. Personalized selection of an appropriate therapeutic strategy directly or indirectly targeting the increased number and/or activity of eosinophils should be based on the understanding of eosinophil homeostasis including their interactions with other immune and non-immune cells within different body compartments. Hence, restoring as well as maintaining homeostasis within an individual's eosinophil pool is a goal of both specific and non-specific eosinophil-targeting therapies. Despite the overall favourable safety profile of the currently available anti-eosinophil biologics, the effect of eosinophil depletion should be monitored from the perspective of possible unwanted consequences.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Allergy
ISSN
0105-4538
e-ISSN
1398-9995
Volume of the periodical
78
Issue of the periodical within the volume
12
Country of publishing house
DK - DENMARK
Number of pages
26
Pages from-to
3077-3102
UT code for WoS article
001068244800001
EID of the result in the Scopus database
2-s2.0-85170692420