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CD14 polymorphism is not associated with SARS-CoV-2 infection in Central European population

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084736" target="_blank" >RIV/00023001:_____/23:00084736 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/23:00134792 RIV/00216208:11110/23:10479301 RIV/00064190:_____/23:10001206

  • Result on the web

    <a href="https://fb.littledata.cz/media/pdf/fb_2023069050181.pdf" target="_blank" >https://fb.littledata.cz/media/pdf/fb_2023069050181.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.14712/fb2023069050181" target="_blank" >10.14712/fb2023069050181</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    CD14 polymorphism is not associated with SARS-CoV-2 infection in Central European population

  • Original language description

    A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (C -&gt; T; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case -control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2positive individuals (P = 0.48; OR; 95 % CI - 0.92; 0.73-1.16). No significant differences in the distribution of genotypes were found when considering codominant and recessive genetic models or various between -group comparisons. The CD14 polymor phism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10603 - Genetics and heredity (medical genetics to be 3)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Folia biologica (Praha)

  • ISSN

    0015-5500

  • e-ISSN

    2533-7602

  • Volume of the periodical

    69

  • Issue of the periodical within the volume

    5-6

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    5

  • Pages from-to

    181-185

  • UT code for WoS article

    001199526300002

  • EID of the result in the Scopus database

    2-s2.0-85190398441