CD14 polymorphism is not associated with SARS-CoV-2 infection in Central European population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084736" target="_blank" >RIV/00023001:_____/23:00084736 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/23:00134792 RIV/00216208:11110/23:10479301 RIV/00064190:_____/23:10001206
Result on the web
<a href="https://fb.littledata.cz/media/pdf/fb_2023069050181.pdf" target="_blank" >https://fb.littledata.cz/media/pdf/fb_2023069050181.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14712/fb2023069050181" target="_blank" >10.14712/fb2023069050181</a>
Alternative languages
Result language
angličtina
Original language name
CD14 polymorphism is not associated with SARS-CoV-2 infection in Central European population
Original language description
A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (C -> T; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case -control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2positive individuals (P = 0.48; OR; 95 % CI - 0.92; 0.73-1.16). No significant differences in the distribution of genotypes were found when considering codominant and recessive genetic models or various between -group comparisons. The CD14 polymor phism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Folia biologica (Praha)
ISSN
0015-5500
e-ISSN
2533-7602
Volume of the periodical
69
Issue of the periodical within the volume
5-6
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
181-185
UT code for WoS article
001199526300002
EID of the result in the Scopus database
2-s2.0-85190398441