Cholesterol associated genetic risk score and acute coronary syndrome in Czech males
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084496" target="_blank" >RIV/00023001:_____/24:00084496 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10478412
Result on the web
<a href="https://link.springer.com/article/10.1007/s11033-023-09128-3#Abs1" target="_blank" >https://link.springer.com/article/10.1007/s11033-023-09128-3#Abs1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11033-023-09128-3" target="_blank" >10.1007/s11033-023-09128-3</a>
Alternative languages
Result language
angličtina
Original language name
Cholesterol associated genetic risk score and acute coronary syndrome in Czech males
Original language description
Background: Despite a general decline in mean levels across populations, LDL-cholesterol levels remain a major risk factor for acute coronary syndrome (ACS). The APOB, LDL-R, CILP, and SORT-1 genes have been shown to contain variants that have significant effects on plasma cholesterol levels.Methods and results: We examined polymorphisms within these genes in 1191 controls and 929 patients with ACS. Only rs646776 within SORT-1 was significantly associated with a risk of ACS (P < 0.05, AA vs. + G comparison; OR 1.21; 95% CI 1.01-1.45). With regard to genetic risk score (GRS), the presence of at least 7 alleles associated with elevated cholesterol levels was connected with increased risk (P < 0.01) of ACS (OR 1.26; 95% CI 1.06-1.52). Neither total mortality nor CVD mortality in ACS subjects (follow up-9.84 ± 3.82 years) was associated with the SNPs analysed or cholesterol-associated GRS.Conclusions: We conclude that, based on only a few potent SNPs known to affect plasma cholesterol, GRS has the potential to predict ACS risk, but not ACS associated mortality.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular biology reports
ISSN
0301-4851
e-ISSN
1573-4978
Volume of the periodical
51
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
"art. no. 164"
UT code for WoS article
001147955900011
EID of the result in the Scopus database
2-s2.0-85182815021