Insights into IL-1 family cytokines in kidney allograft transplantation: IL-18BP and free IL-18 as emerging biomarkers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084891" target="_blank" >RIV/00023001:_____/24:00084891 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1043466624001637?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1043466624001637?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cyto.2024.156660" target="_blank" >10.1016/j.cyto.2024.156660</a>
Alternative languages
Result language
angličtina
Original language name
Insights into IL-1 family cytokines in kidney allograft transplantation: IL-18BP and free IL-18 as emerging biomarkers
Original language description
Proinflammatory cytokines and their inhibitors are involved in the regulation of multiple immune reactions including response to transplanted organs. In this prospective study, we evaluated changes in serum concentrations of six IL-1 family cytokines (IL-1 alpha, IL-1 beta, IL-1RA, IL-18, IL-18BP, and IL-36 beta) in 138 kidney allograft recipients and 48 healthy donors. Samples were collected before transplantation and then after one week, three months and one year, additional sera were obtained at the day of biopsy positive for acute rejection. We have shown, that concentrations of proinflammatory members of the IL-1 family (IL-113, IL-18, IL-36 13) and anti-inflammatory IL-18BP decreased immediately after the transplantation. The decline of serum IL-1RA and IL1 alpha was not observed in subjects with acute rejection. IL-18, including specifically its free form, is the only cytokine which increase serum concentrations in the period between one week and three months in both groups of patients without upregulation of its inhibitor, IL-18BP. Serum concentrations of calculated free IL-18 were upregulated in the acute rejection group at the time of acute rejection. We conclude that IL-1 family cytokines are involved mainly in early phases of the response to kidney allograft. Serum concentrations of free IL-18 and IL18BP represent possible biomarkers of acute rejection, and targeting IL-18 might be of therapeutic value.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
<a href="/en/project/NV15-26883A" target="_blank" >NV15-26883A: Regulatory mechanisms of innate immune cells in kidney transplantation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cytokine
ISSN
1043-4666
e-ISSN
1096-0023
Volume of the periodical
180
Issue of the periodical within the volume
August 2024
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
"art. no. 156660"
UT code for WoS article
001246483500001
EID of the result in the Scopus database
2-s2.0-85193950916