Pruritus, fatigue, osteoporosis and dyslipoproteinemia in Pbc patients: a clinician's perspective

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084903" target="_blank" >RIV/00023001:_____/24:00084903 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2036-7422/15/2/30" target="_blank" >https://www.mdpi.com/2036-7422/15/2/30</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/gastroent15020030" target="_blank" >10.3390/gastroent15020030</a>

Result language

angličtina

Original language name

Pruritus, fatigue, osteoporosis and dyslipoproteinemia in Pbc patients: a clinician's perspective

Original language description

In this review article, we summarize the most common clinical manifestations of Primary biliary cholangitis (PBC): pruritus, fatigue, osteoporosis, and dyslipoproteinemia and discuss their impact of the patients&apos; quality of life. More than half of PBC patients suffer from pruritus or fatigue at the time of diagnosis. We discuss the pathophysiological aspects of the PBC clinical manifestations and treatment options. The pathophysiology of pruritus and fatigue is not adequately elucidated, but IL-31 is associated with the severity of pruritus and could be used to objectify the subjective reporting by questionnaires. Although PBC patients suffer from atherogenic dyslipidemia, they do not seem to have a higher cardiovascular risk; however, this observation needs to be clarified by further clinical studies. The second-line of PBC treatment affects pruritus severity: Obeticholic acid (OCA) worsens pruritus while fibrates improve it. Itching can be alleviated by both non-pharmacological and pharmacological approach, however the are multiple barriers to pharmacological treatment. There is no adequate treatment for fatigue today. Treatment of osteoporosis and dyslipidemia is similar for non-PBC patients; stage of liver disease should be considered in treatment. Further research to clarify the pathophysiology and to eventually discover an effective treatment to improve survival and quality of life (especially pruritus and fatigue) in PBC patients is needed.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Gastroenterology Insights

ISSN

2036-7414

e-ISSN

2036-7422

Volume of the periodical

15

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

419-432

UT code for WoS article

001256556000001

EID of the result in the Scopus database

2-s2.0-85197186789