Self-assembled fluorinated nanoparticles as sensitive and biocompatible theranostic platforms for 19F MRI
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084916" target="_blank" >RIV/00023001:_____/24:00084916 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10477853 RIV/46747885:24530/24:00013002 RIV/00216208:11110/24:10477853
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202300510" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202300510</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.202300510" target="_blank" >10.1002/mabi.202300510</a>
Alternative languages
Result language
angličtina
Original language name
Self-assembled fluorinated nanoparticles as sensitive and biocompatible theranostic platforms for 19F MRI
Original language description
Theranostics is a novel paradigm integrating therapy and diagnostics, thereby providing new prospects for overcoming the limitations of traditional treatments. In this context, perfluorocarbons (PFCs) are the most widely used tracers in preclinical fluorine-19 magnetic resonance (F-19 MR), primarily for their high fluorine content. However, PFCs are extremely hydrophobic, and their solutions often display reduced biocompatibility, relative instability, and subpar F-19 MR relaxation times. This study aims to explore the potential of micellar F-19 MR imaging (MRI) tracers, synthesized by polymerization-induced self-assembly (PISA), as alternative theranostic agents for simultaneous imaging and release of the non-steroidal antileprotic drug clofazimine. In vitro, under physiological conditions, these micelles demonstrate sustained drug release. In vivo, throughout the drug release process, they provide a highly specific and sensitive F-19 MRI signal. Even after extended exposure, these fluoropolymer tracers show biocompatibility, as confirmed by the histological analysis. Moreover, the characteristics of these polymers can be broadly adjusted by design to meet the wide range of criteria for preclinical and clinical settings. Therefore, micellar 19F MRI tracers display physicochemical properties suitable for in vivo imaging, such as relaxation times and non-toxicity, and high performance as drug carriers, highlighting their potential as both diagnostic and therapeutic tools.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular bioscience
ISSN
1616-5187
e-ISSN
1616-5195
Volume of the periodical
24
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
"art. no. 2300510"
UT code for WoS article
001144788700001
EID of the result in the Scopus database
2-s2.0-85182454477