Incidence and risk factors of diabetic foot syndrome in patients early after pancreas or kidney/pancreas transplantation and its association with preventive measures

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084955" target="_blank" >RIV/00023001:_____/24:00084955 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/24:10433337 RIV/00216208:11510/24:10433337

Result on the web

<a href="https://journals.sagepub.com/doi/10.1177/15347346211052155?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed" target="_blank" >https://journals.sagepub.com/doi/10.1177/15347346211052155?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/15347346211052155" target="_blank" >10.1177/15347346211052155</a>

Result language

angličtina

Original language name

Incidence and risk factors of diabetic foot syndrome in patients early after pancreas or kidney/pancreas transplantation and its association with preventive measures

Original language description

Diabetic foot (DF) can develop in diabetic patients after organ transplantation (Tx) due to several factors including peripheral arterial disease (PAD), diabetic neuropathy and inappropriate DF prevention. Aim: To assess the occurrence of DF and associated risk factors in transplant patients. Methods: Fifty-seven diabetic patients were enrolled as part of this prospective study. All patients underwent organ Tx (01/2013-12/2015) and were followed up for minimum of 12 months up to a maximum of 50 months. Over the study period we evaluated DF incidence and identified a number of factors likely to influence DF development, including organ function, presence of late complications, PAD, history of DF, levels of physical activity before and after Tx, patient education and standards of DF prevention. Results: Active DF developed in 31.6% (18/57) of patients after organ Tx within 11 months on average (10.7 +/- 8 months). The following factors significantly correlated with DF development: diabetes control (p = .0065), PAD (p&lt;0.0001), transcutaneous oxygen pressure (TcPO(2;)p = .01), history of DF (p = .0031), deformities (p = .0021) and increased leisure-time physical activity (LTPA) before Tx (p = .037). However, based on logistic stepwise regression analysis, the only factors significantly associated with DF during the post-transplant period were: PAD, deformities and increased LTPA. Education was provided to patients periodically (2.6 +/- 2.5 times) during the observation period. Although 94.7% of patients regularly inspected their feet (4.5 +/- 2.9 times/week), only 26.3% of transplant patients used appropriate footwear. Conclusions: Incidence of DF was relatively high, affecting almost 1/3 of pancreas and kidney/pancreas recipients. The predominant risk factors were: presence of PAD, foot deformities and higher LTPA before Tx. Therefore, we recommend a programme involving more detailed vascular and physical examinations and more intensive education focusing on physical activity and DF prevention in at-risk patients before transplantation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NU20-01-00078" target="_blank" >NU20-01-00078: Rationalisation of ATB Therapy in Diabetic Foot Infection and its Impact on the Intestinal Microbiota</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of lower extremity wounds

ISSN

1534-7346

e-ISSN

1552-6941

Volume of the periodical

23

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

283-290

UT code for WoS article

000723168000001

EID of the result in the Scopus database

2-s2.0-85118388307