The protective role of GATA6
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084972" target="_blank" >RIV/00023001:_____/24:00084972 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S258900422401469X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S258900422401469X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.isci.2024.110244" target="_blank" >10.1016/j.isci.2024.110244</a>
Alternative languages
Result language
angličtina
Original language name
The protective role of GATA6
Original language description
Prior research has suggested that GATA6 + pericardial macrophages may traffic to the myocardium to prevent interstitial fibrosis after myocardial infarction (MI), while subsequent literature claims that they do not. We demonstrate that GATA6 + pericardial macrophages are critical for preventing IL -33 induced pericarditis and attenuate trafficking of inflammatory monocytes and granulocytes to the pericardial cavity after MI. However, absence of GATA6 + macrophages did not affect myocardial inflammation due to MI or coxsackievirus-B3 induced myocarditis, or late -stage cardiac fibrosis and cardiac function post MI. GATA6 + macrophages are significantly less transcriptionally active following stimulation in vitro compared to bone marrow -derived macrophages and do not induce upregulation of inflammatory markers in fibroblasts. This suggests that GATA6 + pericardial macrophages attenuate inflammation through their interactions with surrounding cells. We therefore conclude that GATA6 + pericardial macrophages are critical in modulating pericardial inflammation, but do not play a significant role in controlling myocardial inflammation or fibrosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
iScience
ISSN
2589-0042
e-ISSN
2589-0042
Volume of the periodical
27
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
21
Pages from-to
"art. no. 110244"
UT code for WoS article
001261512200001
EID of the result in the Scopus database
2-s2.0-85196840578