Metabolic changes assessed by 1H MR spectroscopy in the corpus callosum of post-COVID patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00085064" target="_blank" >RIV/00023001:_____/24:00085064 - isvavai.cz</a>

Alternative codes found

RIV/00064190:_____/24:10001303

Result on the web

<a href="https://link.springer.com/article/10.1007/s10334-024-01171-w" target="_blank" >https://link.springer.com/article/10.1007/s10334-024-01171-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10334-024-01171-w" target="_blank" >10.1007/s10334-024-01171-w</a>

Result language

angličtina

Original language name

Metabolic changes assessed by 1H MR spectroscopy in the corpus callosum of post-COVID patients

Original language description

Objective Many patients with long COVID experience neurological and psychological symptoms. Signal abnormalities on MR images in the corpus callosum have been reported. Knowledge about the metabolic profile in the splenium of the corpus callosum (CCS) may contribute to a better understanding of the pathophysiology of long COVID.Materials and methods Eighty-one subjects underwent proton MR spectroscopy examination. The metabolic concentrations of total N-acetylaspartate (NAA), choline-containing compounds (Cho), total creatine (Cr), myo-inositol (mI), and NAA/Cho in the CCS were statistically compared in the group of patients containing 58 subjects with positive IgG COVID-19 antibodies or positive SARS-CoV-2 qPCR test at least two months before the MR and the group of healthy controls containing 23 subjects with negative IgG antibodies.Results An age-dependent effect of SARS-CoV-2 on Cho concentrations in the CCS has been observed. Considering the subjective threshold of age = 40 years, older patients showed significantly increased Cho concentrations in the CCS than older healthy controls (p = 0.02). NAA, Cr, and mI were unchanged. All metabolite concentrations in the CCS of younger post-COVID-19 patients remained unaffected by SARS-CoV-2. Cho did not show any difference between symptomatic and asymptomatic patients (p = 0.91).Discussion Our results suggest that SARS-CoV-2 disproportionately increases Cho concentration in the CCS among older post-COVID-19 patients compared to younger ones. The observed changes in Cho may be related to the microstructural reorganization in the CCS also reported in diffusion measurements rather than increased membrane turnover. These changes do not seem to be related to neuropsychological problems of the post-COVID-19 patients. Further metabolic studies are recommended to confirm these observations.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

<a href="/en/project/NU22-A-124" target="_blank" >NU22-A-124: Changes in brain perfusion and diffusion after COVID-19</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Magnetic resonance materials in physics, biology and medicine (suppl.)

ISSN

1352-8661

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

"937–946"

UT code for WoS article

001245923700001

EID of the result in the Scopus database

2-s2.0-85195636967