Association between FTO polymorphism and COVID-19 mortality among older adults: a population-based cohort study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00085096" target="_blank" >RIV/00023001:_____/24:00085096 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/24:00137283 RIV/00216208:11110/24:10486271 RIV/75010330:_____/24:00014732
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1201971224003035?via%3Dihub#sec0008" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1201971224003035?via%3Dihub#sec0008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijid.2024.107232" target="_blank" >10.1016/j.ijid.2024.107232</a>
Alternative languages
Result language
angličtina
Original language name
Association between FTO polymorphism and COVID-19 mortality among older adults: a population-based cohort study
Original language description
Objectives: COVID-19 caused a global pandemic with millions of deaths. Fat mass and obesity-associated gene (FTO) FTO ) (alias m6A 6 A RNA demethylase) and its functional rs17817449 polymorphism are candidates influence COVID-19-associated mortality since methylation status of viral nucleic acids is an important factor influencing viral viability. Methods: We tested a population-based cohort of 5233 subjects (aged 63-87 years in 2020) where persons died from COVID-19 and 394 from other causes during the pandemic period. Results: The frequency of GG homozygotes was higher among those who died from COVID-19 (34%) among survivors (19%) or deaths from other causes (20%), P < 0.005. After multiple adjustments, GG mozygotes had a higher risk of death from COVID-19 with odds ratio = 2.01 (95% confidence interval; 1.19-3.41, P < 0.01) compared with carriers of at least one T allele. The FTO polymorphism was not ciated with mortality from other causes. Conclusions: Our results suggest that FTO variability is a significant predictor of COVID-19-associated mortality in Caucasians.<br /> (c) 2024 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International journal of infectious diseases
ISSN
1201-9712
e-ISSN
1878-3511
Volume of the periodical
148
Issue of the periodical within the volume
November 2024
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
"art. no. 107232"
UT code for WoS article
001321339500001
EID of the result in the Scopus database
2-s2.0-85204425539