Acute kidney injury in deceased organ donors: risk factors and impacts on transplantation outcomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00085219" target="_blank" >RIV/00023001:_____/24:00085219 - isvavai.cz</a>

Result on the web

<a href="https://journals.lww.com/transplantationdirect/fulltext/2024/12000/acute_kidney_injury_in_deceased_organ_donors__risk.6.aspx" target="_blank" >https://journals.lww.com/transplantationdirect/fulltext/2024/12000/acute_kidney_injury_in_deceased_organ_donors__risk.6.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/TXD.0000000000001730" target="_blank" >10.1097/TXD.0000000000001730</a>

Result language

angličtina

Original language name

Acute kidney injury in deceased organ donors: risk factors and impacts on transplantation outcomes

Original language description

Background.Acute kidney injury in deceased donors (D-AKI) is one of the common causes of donor kidney discard. The risk factors for D-AKI and its impact on kidney transplantation outcomes are not yet fully understood. Methods.This single-center, retrospective cohort study included 388 donors referred between June 2021 and December 2022. D-AKI was defined and staged according to kidney disease: Improving global outcomes criteria, and donor clinical variables were analyzed to identify risk factors for D-AKI. Delayed graft function and estimated glomerular filtration rate (eGFR) at 6 mo were evaluated in 369 kidney grafts transplanted from donors with and without D-AKI. Results.AKI was present in 171 deceased donors (44.1%), with 117 (30.2%) classified as AKI stage 1 and 54 (14%) as AKI stages 2 or 3. Donor history of hypertension (odds ratio [OR] 1.93; 95% confidence interval [CI], 1.21-3.10; P = 0.005), history of diabetes (OR 2.2; 95% CI, 1.21-3.98; P = 0.008), and anoxia as the cause of death (OR 2.61; 95% CI, 1.5-4.61; P &lt; 0.001) were independently associated with an increased risk of D-AKI. Multivariable mixed models identified donor age (beta -0.49; 95% CI, -0.71 to -0.28; P &lt; 0.001) as the only independent risk factor for lower eGFR at 6 mo. D-AKI was not associated with delayed graft function or lower eGFR at 6 mo. Conclusions.Hypertension, diabetes, and anoxia as the cause of death were identified as risk factors for AKI in deceased donors. D-AKI should not be used as the sole criterion to assess the risk of poor graft outcomes. A broader range of donor variables should be considered when evaluating graft viability.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30213 - Transplantation

Project

<a href="/en/project/NU21-06-00021" target="_blank" >NU21-06-00021: Molecular markers of acute kidney injury in elderly deceased donors</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transplantation Direct

ISSN

2373-8731

e-ISSN

2373-8731

Volume of the periodical

10

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

"art. no. e1730"

UT code for WoS article

001354615300004

EID of the result in the Scopus database

2-s2.0-85210359355