Zinc in dermatology: exploring its emerging role in enhancing botulinum toxin formulations and clinical efficacy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00085268" target="_blank" >RIV/00023001:_____/24:00085268 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/1467-3045/46/11/717" target="_blank" >https://www.mdpi.com/1467-3045/46/11/717</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cimb46110717" target="_blank" >10.3390/cimb46110717</a>

Result language

angličtina

Original language name

Zinc in dermatology: exploring its emerging role in enhancing botulinum toxin formulations and clinical efficacy

Original language description

This literature review provides a novel exploration of zinc’s multifaceted roles in dermatology, with a particular focus on its potential integration into botulinum toxin formulations—an area that remains relatively underexplored in clinical practice. Zinc is widely recognized for its critical functions in skin health, including morphogenesis, regeneration, and protection, and its use in aesthetic medicine offers a unique opportunity for innovation. Specifically, incorporating zinc into botulinum toxin formulations could enhance the efficacy and stability of these treatments. Citation: Foster, L.; Foppiani, J.A.; Xun, H.; Lee, D.; Utz, B.; Hernandez Alvarez, A.; Domingo-Escobar, M.J.; Taritsa, I.C.; Gavlasova, D.; Lee, T.C.; et al. Zinc in Dermatology: Exploring Its Emerging Role in Enhancing Botulinum Toxin Formulations and Clinical Efficacy. Curr. Issues Mol. Biol. 2024, 46, 12088–12098. https:// doi.org/10.3390/cimb46110717 Academic Editor: Sherif T. S. Hassan Received: 14 August 2024 Revised: 23 October 2024 Accepted: 25 October 2024 Published: 28 October 2024 Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Although zinc has historically been used in topical dermatological products and systemic health interventions, its potential in cosmetic preparations, such as anti-aging therapies or non-invasive aesthetic treatments, remains under-researched. Emerging patents suggest promising formulations combining zinc with botulinum toxin that may improve product stability and extend therapeutic effects. While current studies on oral zinc supplementation present mixed results concerning its ability to prolong botulinum toxin effects, this underscores the need for more rigorous investigation in the realm of aesthetic medicine. Zinc’s well-established role in stabilizing dermatological products, such as sunscreens, and its applications in wound healing and skin regeneration, further highlights its potential for broader therapeutic uses beyond cosmetic applications. This review identifies a critical gapintheliterature and calls for future research to optimize zinc concentrations and delivery methods specifically for aesthetic medical procedures, offering new insights into improving dermatological treatments beyond the scope of traditional cosmetic preparations.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current issues in molecular biology

ISSN

1467-3037

e-ISSN

1467-3045

Volume of the periodical

46

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

12088-12098

UT code for WoS article

001364147300001

EID of the result in the Scopus database

2-s2.0-85210426401