Glucagon-like peptide-1 receptor agonists and muscle mass effects
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085818" target="_blank" >RIV/00023001:_____/25:00085818 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/25:10515663
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1043661825003524?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1043661825003524?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.phrs.2025.107927" target="_blank" >10.1016/j.phrs.2025.107927</a>
Alternative languages
Result language
angličtina
Original language name
Glucagon-like peptide-1 receptor agonists and muscle mass effects
Original language description
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have transformed the management of obesity, demonstrating significant efficacy in inducing weight loss and improving metabolic parameters. However, emerging clinical and paraclinical evidence suggests that these agents may also contribute to an unintended reduction in skeletal muscle mass, potentially exacerbating or precipitating sarcopenic obesity, particularly in older or frail individuals with limited muscular reserves. This review critically examines current data on the effects of GLP-1 RAs on body composition, explores the underlying pathophysiological mechanisms of skeletal muscle wasting, and offers evidence-based strategies for attenuating these potential adverse outcomes. While GLP-1 RAs therapy remains central to obesity management, optimizing its use through early recognition and management of associated risks is essential to preserve muscular health, patient functional status and quality of life.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacological research
ISSN
1043-6618
e-ISSN
1096-1186
Volume of the periodical
220
Issue of the periodical within the volume
October 2025
Country of publishing house
GB - UNITED KINGDOM
Number of pages
19
Pages from-to
"art. no. 107927"
UT code for WoS article
001561951000001
EID of the result in the Scopus database
2-s2.0-105014122899