Life Expectancy of Transplanted Livers: HOPE Against Aging?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085891" target="_blank" >RIV/00023001:_____/25:00085891 - isvavai.cz</a>
Result on the web
<a href="https://journals.lww.com/annalsofsurgery/fulltext/2025/11000/life_expectancy_of_transplanted_livers__hope.13.aspx" target="_blank" >https://journals.lww.com/annalsofsurgery/fulltext/2025/11000/life_expectancy_of_transplanted_livers__hope.13.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/SLA.0000000000006883" target="_blank" >10.1097/SLA.0000000000006883</a>
Alternative languages
Result language
angličtina
Original language name
Life Expectancy of Transplanted Livers: HOPE Against Aging?
Original language description
Objective: To investigate the impact of cumulative liver age on graft survival in liver transplant recipients. Background: Organ shortage has led to increased use of elderly donor livers for an ageing group of recipients, particularly in Europe. We hypothesized that hypothermic oxygenated perfusion (HOPE) enhances graft resilience against aging in livers from elderly donors. Methods: This post hoc analysis of the multicenter European HOPE-REAL study (NCT05520320) examined liver age in adult recipients of HOPE-treated brain-dead donor (DBD) livers. Cumulative liver age was defined as the sum of donor age and post-transplant graft survival. HOPE-treated DBD liver transplants were compared with a single-center control cohort of non-perfused DBD livers using propensity score matching to adjust for confounders. Results: The median cumulative liver age was significantly higher in the HOPE-treated (n=768) cohort than in the non-perfused (n=863) group (69 vs 61 years, P<0.001), yet graft survival was superior in the HOPE-treated group (log-rank P<0.001). After matching, cumulative liver age remained significantly higher in the HOPE group (P<0.001). Multivariate analysis identified HOPE as an independent predictor of cumulative liver age (P<0.001). Conclusions: HOPE treatment seems to mitigate the risks associated with transplanting elderly DBD livers, leading to excellent long-term survival in an ageing recipient population. These findings support broader adoption of HOPE to improve utilization of older donor livers and expand the donor pool.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30212 - Surgery
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annals of surgery
ISSN
0003-4932
e-ISSN
1528-1140
Volume of the periodical
282
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
765-771
UT code for WoS article
001591650000015
EID of the result in the Scopus database
2-s2.0-105012976603